IED Industry Enzyme Database

Detail Information for IndEnz0002001753
IED ID IndEnz0002001753
Enzyme Type ID protease001753
Protein Name Tumor necrosis factor receptor superfamily member 6
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD antigen CD95
Gene Name Fas Apt1 Tnfrsf6
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNCSEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTLCDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTNCRKQSPRNRLWLLTILVLLIPLVFIYRKYRKRKCWKRRQDDPESRTSSRETIPMNASNLSLSKYIPRIAEDMTIQEAKKFARENNIKEGKIDEIMHDSIQDTAEQKVQLLLCWYQSHGKSDAYQDLIKGLKKAECRRTLDKFQDMVQKDLGKSTPDTGNENEGQCLE
Enzyme Length 327
Uniprot Accession Number P25446
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (1); Disulfide bond (9); Domain (1); Glycosylation (2); Helix (2); Lipidation (1); Modified residue (4); Natural variant (1); Region (3); Repeat (3); Sequence conflict (3); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords 3D-structure;Apoptosis;Calmodulin-binding;Cell membrane;Disease variant;Disulfide bond;Glycoprotein;Lipoprotein;Membrane;Palmitate;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix
Interact With O89110; O35613; Q61160; Q9ERH7; Q60953; Q9UER7; Q13158
Induction INDUCTION: Expression oscillates in a circadian manner in the liver with peak levels seen at CT12. {ECO:0000269|PubMed:23785138}.
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51867}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P51867}. Membrane raft {ECO:0000250|UniProtKB:P25445}.
Modified Residue MOD_RES 206; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 217; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:21183079"; MOD_RES 220; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"; MOD_RES 314; /note="Phosphothreonine"; /evidence="ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
Post Translational Modification PTM: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. {ECO:0000250|UniProtKB:P25445}.
Signal Peptide SIGNAL 1..21; /evidence=ECO:0000255
Structure 3D NMR spectroscopy (1); X-ray crystallography (1)
Cross Reference PDB 2NA6; 3OQ9;
Mapped Pubmed ID 10049941; 10051411; 10072523; 10082135; 10086384; 10092780; 10196250; 10202001; 10209037; 10209045; 10209520; 10352252; 10355966; 10359584; 10370375; 10383935; 10384136; 10393694; 10395644; 10429671; 10438978; 10440569; 10442092; 10452986; 10453074; 10477549; 10477553; 10477582; 10485649; 10490975; 10497009; 10497129; 10510373; 10515865; 10527913; 10534118; 10550220; 10553053; 10583610; 10585755; 10586090; 10588860; 10594844; 10597256; 10600221; 10607487; 10619357; 10620607; 10620618; 10623824; 10640767; 10657611; 10671227; 10675763; 10679090; 10706679; 10706715; 10711700; 10712254; 10713354; 10728678; 10744644; 10744653; 10759366; 10760784; 10791994; 10820290; 10878371; 10878381; 10880532; 10898516; 10903773; 10932231; 10946317; 10950807; 10950869; 10975864; 10980337; 11016428; 11035071; 11046004; 11063826; 11067740; 11067882; 11067900; 11086022; 11106570; 11113135; 11115362; 11157873; 11159055; 11180800; 11217851; 11239407; 11241200; 11247634; 11254672; 11274068; 11290816; 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Motif
Gene Encoded By
Mass 37,437
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda