IED ID | IndEnz0002001754 |
Enzyme Type ID | protease001754 |
Protein Name |
Tricorn protease homolog 1 EC 3.4.21.- |
Gene Name | tri1 SCO2549 SCC77.16c |
Organism | Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Actinobacteria Actinomycetia (high G+C Gram-positive bacteria) Streptomycetales Streptomycetaceae Streptomyces Streptomyces albidoflavus group Streptomyces coelicolor Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) |
Enzyme Sequence | MGVTQPAAPAYLRFPHPHGELVAFTAEDDVWLAPLDGGRAWRVSADNVPVNHPRISPDGTKVAWTSTRDGAPEVHVAPVEGGPAKRLTHWGSIRTQVRGWTADGRVLALSTYGQASLRRSWARALPLDGGPATTLPYGPVGDVAQGPHTVLLSAPMGREAAWWKRYRGGTAGKLWIDREDDGEFVRLHDGLDGNIEYPFWVGDRIAFLSDHEGTGALYSSLADGSDLRRHTPVDGFYARHAATDGSRVVYASAGELWTLDDLDGAEPRRLDIRLGGARVDLQSYPVNAARWFGSASPDHTARGSAVAVRGGVHWVTHRSGPARALAATPGVRNRLPRTFRVDGEEWVVWVTDAEGDDALEFAPATGLAPGATARRLAAGQLGRVLHLAVAPDGSRVAVASHDGRVLLVERESGEVREVDRSEDGDASGLVFSPDSSWLAWSHPGPEPLRQLKLANTTDLSVSEATPLRFKDYSPAFTLDGKHLAFLSTRSFDPVYDEHVFDLAFVEGARPYLITLAATTPSPFGPQRHGRPFETPDREETPDSEGTPTTRIDIEGLADRIVPFPVEAARYSRLRAAKDGVLWLRHPLTGVLGASRANPEDPDPNTELERYDLAQQRVEHLGGDADHFEVSGDGKRVLLWTDGRLKVVPSDRRASGDEDSDTNITVDLGRVRQTVEPAAEWRQMFDETGRIMRDHYWRADMNGVDWDGVLDRYRPVLDRVATHDDLVDLLWEVHGELGTSHAYVTPRGGHGSGARQGLLGADLSRHEDGAWRIDRVLPSETSDPDARSPLAAPGVAVRAGDAIVAVAGQAVDPVTGPGPLLVGTAGKPVELTVSPSGGGEVRHAVVVPLADEEPLRYHAWVADRRAYVHEKSGGRLGYLHVPDMQAPGWAQIHRDLRVEVAREGLVVDVRENRGGHTSQLVVEKLARRIVGWDLPRGMRPTSYPQDAPRGPVVAVANEFSGSDGDIVNAAIKALGIGPVVGVRTWGGVIGIDSRYRLVDGTLITQPKYAFWLEGYGWGVENHGVDPDVEVPQRPQDHAAGRDPQLDEAIALALAALEETPAKTPPSLP |
Enzyme Length | 1067 |
Uniprot Accession Number | Q9RDE2 |
Absorption | |
Active Site | ACT_SITE 740; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 961; /note=Nucleophile; /evidence=ECO:0000250|UniProtKB:P96086; ACT_SITE 1019; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P96086 |
Activity Regulation | ACTIVITY REGULATION: Stimulated by MgCl2. |
Binding Site | BINDING 914; /note=Substrate; via amide nitrogen; /evidence=ECO:0000250|UniProtKB:P96086 |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.21.- |
Enzyme Function | FUNCTION: Degrades oligopeptides in a sequential manner. {ECO:0000250}. |
Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 37 degrees Celsius.; |
PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.5-7.8.; |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Binding site (1); Chain (1); Compositional bias (1); Region (2); Site (1) |
Keywords | Cytoplasm;Hydrolase;Protease;Reference proteome;Serine protease |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 115,647 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |