Detail Information for IndEnz0002001755
IED ID IndEnz0002001755
Enzyme Type ID protease001755
Protein Name Tumor necrosis factor receptor superfamily member 6
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD antigen CD95
Gene Name Fas Apt1 Tnfrsf6
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MLWIMAVLPLVLAGPELNVRMQGTDSIFEGLELKRSVRETDNNCSEGLYQVGPFCCQPCQPGERKVKDCTTSGGAPTCHPCTEGEEYTDRKHYSDKCRRCAFCDEGHGLEVETNCTRTQNTKCRCKENFYCNASLCDHCYHCTSCGLEDILEPCTRTSNTKCKKQSSNYKLLWLLILPGLAILFVFIYKRYRKRQPGDPESGIPSPESVPMNVSDVNLNKYIWRTAEKMKICDAKKFARQHKIPESKIDEIEHNSPQDAAEQKIQLLQCWYQSHGKTGACQALIQGLRKANRCDIAEEIQAMVWEDHENSISNSRNENEGQSLE
Enzyme Length 324
Uniprot Accession Number Q63199
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (9); Domain (1); Glycosylation (3); Modified residue (1); Region (2); Repeat (3); Signal peptide (1); Topological domain (2); Transmembrane (1)
Keywords Apoptosis;Calmodulin-binding;Cell membrane;Disulfide bond;Glycoprotein;Lipoprotein;Membrane;Palmitate;Phosphoprotein;Receptor;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51867}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P51867}. Membrane raft {ECO:0000250|UniProtKB:P25445}.
Modified Residue MOD_RES 214; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P25445
Post Translational Modification PTM: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. {ECO:0000250|UniProtKB:P25445}.
Signal Peptide SIGNAL 1..21; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10024361; 10029626; 10084951; 10386469; 10632538; 10678925; 10715265; 11331665; 11332701; 11435933; 12031707; 12111799; 12522536; 12683940; 12861046; 14530904; 14679192; 14699504; 15038834; 15039424; 15254243; 15309723; 15487762; 15519734; 15528299; 15557468; 15777748; 15796164; 16000635; 16078565; 16099864; 16152783; 16154149; 16222447; 16226958; 16337971; 16392621; 16461545; 16493077; 16582846; 16609999; 16616089; 16687611; 16761189; 16796407; 16831245; 16870148; 16936193; 16953119; 16987298; 17045251; 17105443; 17195944; 17235585; 17441510; 17518537; 17703359; 17899301; 17900647; 17923548; 17953211; 17959308; 17991709; 18045865; 18204739; 18246871; 18289516; 18407603; 18410517; 18427836; 18561025; 18692025; 18981705; 19001025; 19039600; 19107989; 19151726; 19239001; 19267062; 19399403; 19407976; 19415683; 19616844; 19642903; 19820199; 19823951; 19902128; 20428798; 20448356; 20568470; 21316771; 21330946; 21384494; 21421874; 21586345; 21843499; 21868309; 22368862; 22609371; 23441449; 23934157; 23934924; 23940767; 23973665; 24307234; 24324791; 24938610; 25294749; 25310648; 25439027; 26316710; 27561622; 27606894; 27919821; 27939985; 28346613; 28501275; 28595623; 28722192; 29208459; 29213335; 29285062; 29324390; 29339218; 29522769; 29568770; 29588340; 29606031; 29634416; 29713367; 29738767; 29746994; 29844269; 29852394; 29891925; 29970988; 30122878; 30172001; 31155748; 33847039; 33994507; 8612534; 9253159; 9927315;
Motif
Gene Encoded By
Mass 36,835
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda