IED ID | IndEnz0002001758 |
Enzyme Type ID | protease001758 |
Protein Name |
Signal peptide peptidase-like 2 AtSPPL2 EC 3.4.23.- |
Gene Name | SPPL2 At1g63690 F24D7.12 |
Organism | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
Enzyme Sequence | MDSLRFLRILLLSSSILLLSLRSTVTAGDIVHQDNLAPKKPGCENDFVLVKVQTWIDGVENEEFVGVGARFGKRIVSKEKNANQTHLVFANPRDSCTPLKNKLSGDVVIVERGNCRFTAKANNAEAAGASALLIINNQKELYKMVCEPDETDLDIQIPAVMLPQDAGASLQKMLANSSKVSAQLYSPRRPAVDVAEVFLWLMAIGTILCASYWSAWSAREAAIEHDKLLKDAIDEIPNTNDGGSGVVEINSISAIFFVVLASGFLVILYKLMSYWFVELLVVVFCIGGVEGLQTCLVALLSRWFQRAADTYVKVPFLGPISYLTLAVSPFCIVFAVLWAVYRVHSFAWIGQDVLGIALIITVLQIVHVPNLKVGTVLLSCAFLYDIFWVFVSKKLFHESVMIVVARGDKSGEDGIPMLLKIPRMFDPWGGYSIIGFGDILLPGLLIAFALRYDWLANKTLRTGYFIWAMVAYGLGLLITYVALNLMDGHGQPALLYIVPFTLGTMLTLARKRDDLWILWTKGEPERACPHHVRLEQCSEK |
Enzyme Length | 540 |
Uniprot Accession Number | Q8W469 |
Absorption | |
Active Site | ACT_SITE 385; /evidence=ECO:0000250; ACT_SITE 438; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.23.- |
Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Chain (1); Domain (1); Erroneous gene model prediction (1); Glycosylation (2); Motif (1); Sequence conflict (3); Signal peptide (1); Topological domain (10); Transmembrane (9) |
Keywords | Alternative splicing;Endosome;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18067581}; Multi-pass membrane protein {ECO:0000269|PubMed:18067581}. |
Modified Residue | |
Post Translational Modification | PTM: Glycosylated. {ECO:0000250}. |
Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | MOTIF 492..494; /note=PAL |
Gene Encoded By | |
Mass | 59,837 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |