Detail Information for IndEnz0002001758
IED ID IndEnz0002001758
Enzyme Type ID protease001758
Protein Name Signal peptide peptidase-like 2
AtSPPL2
EC 3.4.23.-
Gene Name SPPL2 At1g63690 F24D7.12
Organism Arabidopsis thaliana (Mouse-ear cress)
Taxonomic Lineage cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress)
Enzyme Sequence MDSLRFLRILLLSSSILLLSLRSTVTAGDIVHQDNLAPKKPGCENDFVLVKVQTWIDGVENEEFVGVGARFGKRIVSKEKNANQTHLVFANPRDSCTPLKNKLSGDVVIVERGNCRFTAKANNAEAAGASALLIINNQKELYKMVCEPDETDLDIQIPAVMLPQDAGASLQKMLANSSKVSAQLYSPRRPAVDVAEVFLWLMAIGTILCASYWSAWSAREAAIEHDKLLKDAIDEIPNTNDGGSGVVEINSISAIFFVVLASGFLVILYKLMSYWFVELLVVVFCIGGVEGLQTCLVALLSRWFQRAADTYVKVPFLGPISYLTLAVSPFCIVFAVLWAVYRVHSFAWIGQDVLGIALIITVLQIVHVPNLKVGTVLLSCAFLYDIFWVFVSKKLFHESVMIVVARGDKSGEDGIPMLLKIPRMFDPWGGYSIIGFGDILLPGLLIAFALRYDWLANKTLRTGYFIWAMVAYGLGLLITYVALNLMDGHGQPALLYIVPFTLGTMLTLARKRDDLWILWTKGEPERACPHHVRLEQCSEK
Enzyme Length 540
Uniprot Accession Number Q8W469
Absorption
Active Site ACT_SITE 385; /evidence=ECO:0000250; ACT_SITE 438; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Domain (1); Erroneous gene model prediction (1); Glycosylation (2); Motif (1); Sequence conflict (3); Signal peptide (1); Topological domain (10); Transmembrane (9)
Keywords Alternative splicing;Endosome;Glycoprotein;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18067581}; Multi-pass membrane protein {ECO:0000269|PubMed:18067581}.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000250}.
Signal Peptide SIGNAL 1..27; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 492..494; /note=PAL
Gene Encoded By
Mass 59,837
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda