| IED ID | IndEnz0002001760 |
| Enzyme Type ID | protease001760 |
| Protein Name |
Signal peptide peptidase-like 1 AtSPPL1 EC 3.4.23.- |
| Gene Name | SPPL1 At4g33410 F17M5.170 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | METLWTLLYLLEPAPATLIVTAVTVTFASAFRALNYGKEMERNRDFSEASITLDSSQALMIPVMSSCSLLLMFYLFSSVSQLLTAFTAIASVSSLFYWLSPYAVYMKTQLGLSDPFLSRCCSKSFTRIQGLLLVACAMTVVAWLISGHWVLNNLLGISICIAFVSHVRLPNIKICAMLLVCLFVYDIFWVFFSERFFGANVMVAVATQQASNPVHTVANSLNLPGLQLITKKLELPVKIVFPRNLLGGVVPGVSASDFMMLGLGDMAIPAMLLALVLCFDHRKTRDVVNIFDLKSSKGHKYIWYALPGYAIGLVAALAAGVLTHSPQPALLYLVPSTLGPVIFMSWRRKDLAELWEGPALSNPIEKSHEIEI |
| Enzyme Length | 372 |
| Uniprot Accession Number | Q93Z32 |
| Absorption | |
| Active Site | ACT_SITE 186; /evidence=ECO:0000250; ACT_SITE 265; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Erroneous gene model prediction (2); Motif (1); Topological domain (10); Transmembrane (9) |
| Keywords | Endosome;Hydrolase;Membrane;Protease;Reference proteome;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18067581}; Multi-pass membrane protein {ECO:0000269|PubMed:18067581}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 18650403; 18775970; |
| Motif | MOTIF 328..330; /note=PAL |
| Gene Encoded By | |
| Mass | 41,002 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |