| IED ID | IndEnz0002001769 |
| Enzyme Type ID | protease001769 |
| Protein Name |
Serine proteinase inhibitor 2 Serp-2 Serpin-2 Cytokine response modifier protein A Hemorrhage-inducing 38 kDa protein ICE inhibitor |
| Gene Name | CRMA SPI-2 CPXV207 |
| Organism | Cowpox virus (strain Brighton Red) (CPV) |
| Taxonomic Lineage | Viruses Varidnaviria Bamfordvirae Nucleocytoviricota Pokkesviricetes Chitovirales Poxviridae Chordopoxvirinae Orthopoxvirus Cowpox virus (CPV) Cowpox virus (strain Brighton Red) (CPV) |
| Enzyme Sequence | MDIFREIASSMKGENVFISPPSISSVLTILYYGANGSTAEQLSKYVEKEADKNKDDISFKSMNKVYGRYSAVFKDSFLRKIGDNFQTVDFTDCRTVDAINKCVDIFTEGKINPLLDEPLSPDTCLLAISAVYFKAKWLMPFEKEFTSDYPFYVSPTEMVDVSMMSMYGEAFNHASVKESFGNFSIIELPYVGDTSMVVILPDNIDGLESIEQNLTDTNFKKWCDSMDAMFIDVHIPKFKVTGSYNLVDALVKLGLTEVFGSTGDYSNMCNSDVSVDAMIHKTYIDVNEEYTEAAAATCALVADCASTVTNEFCADHPFIYVIRHVDGKILFVGRYCSPTTN |
| Enzyme Length | 341 |
| Uniprot Accession Number | P07385 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Specific and potent inhibitor of the interleukin-1-beta converting enzyme (ICE) thereby suppressing an interleukin-1 beta response to infection. The inhibition of ICE by crmA is an example of a 'cross-class' interaction, in which a serpin inhibits a non-serine proteinase. Also inhibits granzyme B. {ECO:0000269|PubMed:1339309, ECO:0000269|PubMed:8034697}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (20); Chain (1); Helix (10); Site (1); Turn (4) |
| Keywords | 3D-structure;Host cytoplasm;Host-virus interaction;Inhibition of host caspases by virus;Modulation of host cell apoptosis by virus;Protease inhibitor;Thiol protease inhibitor |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (3) |
| Cross Reference PDB | 1C8O; 1F0C; 1M93; |
| Mapped Pubmed ID | 10903953; 10975564; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,077 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |