IED ID | IndEnz0002001770 |
Enzyme Type ID | protease001770 |
Protein Name |
Serine protease inhibitor 1 PSPI-21 PSPI-21-6.3 Cleaved into: Serine protease inhibitor 1 chain A; Serine protease inhibitor 1 chain B |
Gene Name | |
Organism | Solanum tuberosum (Potato) |
Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae asterids lamiids Solanales Solanaceae Solanoideae Solaneae Solanum Solanum tuberosum (Potato) |
Enzyme Sequence | MKCLFLVCLCLVPIVVFSSTFTSQNPINLPSDATPVLDVTGKELDSRLSYRIISTFWGALGGDVYLGKSPNSDAPCANGVFRYNSDVGPSGTPVRFIGSSSHFGQGIFENELLNIQFAISTSKLCVSYTIWKVGDYDASLGTMLLETGGTIGQADSSWFKIVKSSQLGYNLLYCPVTSTMSCPFSSDDQFCLKVGVVHQNGKRRLALVKDNPLDISFKQVQ |
Enzyme Length | 221 |
Uniprot Accession Number | P58514 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Potent inhibitor of serine proteases (chymotrypsin and trypsin). Inhibits tightly human leukocyte elastase (HLE). Does not inhibit papain, pepsin nor cathepsin D (cysteine and aspartic proteases). Protects the plant by inhibiting proteases of invading organisms, decreasing both hyphal growth and zoospores germination of Phytophthora infestans. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (2); Disulfide bond (2); Motif (1); Propeptide (2); Signal peptide (1); Site (2) |
Keywords | Direct protein sequencing;Disulfide bond;Protease inhibitor;Reference proteome;Serine protease inhibitor;Signal;Vacuole |
Interact With | |
Induction | INDUCTION: By infection with Phytophthora infestans. |
Subcellular Location | SUBCELLULAR LOCATION: Vacuole {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | PTM: Synthesized as a single-chain precursor which is cleaved to form chain A and chain B. |
Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | MOTIF 25..30; /note=Vacuolar targeting signal; /evidence=ECO:0000250 |
Gene Encoded By | |
Mass | 24,009 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |