| IED ID | IndEnz0002001787 |
| Enzyme Type ID | protease001787 |
| Protein Name |
Trypsin 5G1 EC 3.4.21.4 |
| Gene Name | AAEL013712 |
| Organism | Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Nematocera Culicomorpha Culicoidea Culicidae (mosquitos) Culicinae Aedini Aedes Stegomyia Aedes aegypti (Yellowfever mosquito) (Culex aegypti) |
| Enzyme Sequence | MTRIILILTATFFACALGASTGGSHPLRPWWNALRSSGRIVGGFEVPVEEVPFQVSLSGVGSSHFCGGSLLSERWVMTAGHCAASGQTNLQVRIGSSQHASGGQLIKVKKVNRHPKYDEVTTDYDFALLELEETVTFSDSCAPVKLPQKDAPVNEGTCLQVSGWGNTQNPSESSEVLRAAYVPAVSQKECHKAYLSFGGVTDRMVCAGFKEGGKDSCQGDSGGPLVHDNTLVGVVSWGYGCAQAGYPGVYARVASVRDWVKEVSGL |
| Enzyme Length | 266 |
| Uniprot Accession Number | P29787 |
| Absorption | |
| Active Site | ACT_SITE 81; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 125; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 221; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.; EC=3.4.21.4; |
| DNA Binding | |
| EC Number | 3.4.21.4 |
| Enzyme Function | FUNCTION: Major function may be to aid in digestion of the blood meal. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Domain (1); Frameshift (1); Propeptide (1); Sequence conflict (1); Signal peptide (1); Site (1) |
| Keywords | Digestion;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 28,246 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |