| IED ID | IndEnz0002001818 |
| Enzyme Type ID | protease001818 |
| Protein Name |
Serine protease inhibitor A3K Serpin A3K CPI-21 Contrapsin-like protease inhibitor 1 GHR-P63 Growth hormone-regulated proteinase inhibitor Kallikrein-binding protein KBP SPI-2.3 Serine protease inhibitor 2 SPI-2 Thyroid hormone-regulated protein |
| Gene Name | Serpina3k Spin2b |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MAFIAALGLLMAGICPAVLCDGILGRDTLPHEDQGKGRQLHSLTLASINTDFTLSLYKKLALRNPDKNVVFSPLSISAALAILSLGAKDSTMEEILEVLKFNLTEITEEEIHQGFGHLLQRLSQPEDQAEINTGSALFIDKEQPILSEFQEKTRALYQAEAFVADFKQCNEAKKFINDYVSNQTQGKIAELFSELDERTSMVLVNYLLFKGKWKVPFNPNDTFESEFYLDEKRSVKVPMMKIKDLTTPYIRDEELSCSVLELKYTGNASALFILPDQGKMQQVESSLQPETLKKWKDSLRPRIISELRMPKFSISTDYNLEEVLPELGIRKIFSQQADLSRITGTKNLHVSQVVHKAVLDVDETGTEGAAATAVTAALKSLPQTIPLLNFNRPFMLVITDNNGQSVFFMGKVTNPM |
| Enzyme Length | 416 |
| Uniprot Accession Number | P05545 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase. {ECO:0000269|PubMed:1864837, ECO:0000269|PubMed:2440672}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (3); Glycosylation (4); Natural variant (1); Region (1); Sequence conflict (12); Signal peptide (1); Site (1) |
| Keywords | Direct protein sequencing;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | INDUCTION: By growth hormone, thyroid hormone and sex hormones. Its expression is reduced by inflammation. In male rats, its level is several fold higher than in female rats. Reduced during acute inflammation. {ECO:0000269|PubMed:1694763, ECO:0000269|PubMed:2398056, ECO:0000269|PubMed:2440672, ECO:0000269|PubMed:3494016}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:1694763, ECO:0000269|PubMed:2440672}. |
| Signal Peptide | SIGNAL 1..20; /evidence=ECO:0000269|PubMed:2398056 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12743698; 18762777; 20081110; 20299474; 20351274; 21693707; 22206666; 23129128; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,562 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |