Detail Information for IndEnz0002001826
IED ID IndEnz0002001826
Enzyme Type ID protease001826
Protein Name Probable extracellular metalloproteinase 5
EC 3.4.24.-
Fungalysin MEP5
Gene Name MEP5 ARB_06472
Organism Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Arthroderma benhamiae (Trichophyton mentagrophytes) Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Enzyme Sequence MHGLLLAAAGLLSLPLHVLAHPQPSTNLAGRGVDLDAYRMADRSSYMSSDDMKLKQPAIASLSGGNYVDTATEVVKRMMPGMTFRMVDDHYVGESGISHVYFRQTMHGMDIDNADFNVNIGKDGKVLSLGHSFYTGPAPDKAPVEKRDFSDPMQAFHGACKALNLPINADKATIQTMNEHEVMFMGTSGAMSDPQGKLCYMAKEDGTLALTWRVETDMGDNWLLSYVDAKETDKVHNVVDYVSHATYQVYKWPIPDPTEGKREIVQNPWNLKTSPFTWISDGKTNYTTTRGNNAIAQANFDGGEDYLNNYRPDSKNLKFEYPYAPNMSPPKSYIDASVTQLFYSANMVHDLYYMLGFTEKAGNFQVNNRGQGGKGNDFVILNAQDGSGTNNANFATPPDGKPGRMRVYIWTKAKPSRDSSFEAGTVIHEYTHGLSNRLCGGPANAGCLNGMESGGMGEGWGDFFATAIRLKPNDNRNSNYVHGEWVNNSPKGNRLYPYSTNLQTNPLVYTSCNKYNEVHAIGTVWCSILYEVLWNLIDKHGKNDGPTPVFENGVPNDGKYLALKLVLDGMAIQPCKPTFVQARDAIIDADMNLTKGSNKCELWKAFAKRGLGVGAKYDPKNRTGSKAVPKECQ
Enzyme Length 633
Uniprot Accession Number D4AQG5
Absorption
Active Site ACT_SITE 429; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Secreted metalloproteinase probably acting as a virulence factor. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Glycosylation (3); Metal binding (2); Propeptide (1); Signal peptide (1)
Keywords Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Secreted;Signal;Virulence;Zinc;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..20; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 69,841
Kinetics
Metal Binding METAL 428; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095; METAL 432; /note=Zinc; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU10095
Rhea ID
Cross Reference Brenda