| IED ID | IndEnz0002001830 |
| Enzyme Type ID | protease001830 |
| Protein Name |
Vacuolar membrane protease EC 3.4.-.- FXNA-related family protease 1 |
| Gene Name | AO090009000488 |
| Organism | Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus oryzae (Yellow koji mold) Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold) |
| Enzyme Sequence | MASLRLPRANPLAFTRWPVTVITAIVYLALLIPLLVVHHVVPSAPSSPPSGLNISEAWADLQVLTNGFHPYNSRRNDVIHSWLLRRINEILDSTPLEQEYRALDEEKPDVFVFDDVYSNLTTYGGTLKDADLGVYFEGTNVIVYIRGWEDDTEHWWEAPNGVPTSRGGVLVNSHYDSVSTGFGATDDGVGVVTCLQLVKYFTTPGHAPRRGLVVLFNNGEEDFLNGARVYSQHPISKLPHTFLNLEGAGAGGRATLFRSSDFEVTGPYMRSPHPFGSVLSANGFDTGLIASQTDYVIFQGNMGLRGLDVAFMEPRARYHTNQDDTRHTSKDSVWHMLSAAVATTEGLVSDSTDRFDGAPNTDGGVPSGSGSQAVWFDLFGSTFVLFQLHTLFALLVTLLIVGPLTLLFTSIALTKADKMYLFRSSAKSEDRLDVVPLQGLRGFFRFPFLFGIPTVVTVGLAYLVTKVNPYIIHSSAYAVWSMMVAAWVFLAWFVSRVADFARPSAFHRIYTLTWMYVLSWVSAVIATVYANQRGLAGGYFIFFFHAGIFLAKWISYLELFALPSKTEYANQLRSASGRASGHGSRRGTTSGEDDGEEAEEEPTESTSLLGSGQRTTFANYVRVGGDNHAVAEEEVIDPNVYGREQAWSYALPKWTWVLQLLLTAPITLIMVGPLALLTISAISQTGQDGGHPLFAYVAIAIFTTIMLTPLLPFIHRYTYHVPLFLLAVFLGTLIYNLVAFPFSDSNRLKLYYVQEVDLDTGVNSATFAGLSPFVKDVSQELPSAAGQTVSCEWHTKRRNLLSCSWEGIAPQPVEGDHPMKDWVSFNISKSTDKPQARFEVSGLNTRACRILFDTPVKNFHVAGSAYDPRFPYDAAGVNEIRLWSRTWENQWTVDVDWDEGALKGNVVCLWSDHNQPGVLPALDEAIQFLPVWAAVTKGSDGLVEGRRAFEIGNDD |
| Enzyme Length | 955 |
| Uniprot Accession Number | Q2UU23 |
| Absorption | |
| Active Site | ACT_SITE 220; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (3); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9) |
| Keywords | Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 105,601 |
| Kinetics | |
| Metal Binding | METAL 174; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 186; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 186; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 221; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 246; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 319; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |