Detail Information for IndEnz0002001830
IED ID IndEnz0002001830
Enzyme Type ID protease001830
Protein Name Vacuolar membrane protease
EC 3.4.-.-
FXNA-related family protease 1
Gene Name AO090009000488
Organism Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus oryzae (Yellow koji mold) Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold)
Enzyme Sequence MASLRLPRANPLAFTRWPVTVITAIVYLALLIPLLVVHHVVPSAPSSPPSGLNISEAWADLQVLTNGFHPYNSRRNDVIHSWLLRRINEILDSTPLEQEYRALDEEKPDVFVFDDVYSNLTTYGGTLKDADLGVYFEGTNVIVYIRGWEDDTEHWWEAPNGVPTSRGGVLVNSHYDSVSTGFGATDDGVGVVTCLQLVKYFTTPGHAPRRGLVVLFNNGEEDFLNGARVYSQHPISKLPHTFLNLEGAGAGGRATLFRSSDFEVTGPYMRSPHPFGSVLSANGFDTGLIASQTDYVIFQGNMGLRGLDVAFMEPRARYHTNQDDTRHTSKDSVWHMLSAAVATTEGLVSDSTDRFDGAPNTDGGVPSGSGSQAVWFDLFGSTFVLFQLHTLFALLVTLLIVGPLTLLFTSIALTKADKMYLFRSSAKSEDRLDVVPLQGLRGFFRFPFLFGIPTVVTVGLAYLVTKVNPYIIHSSAYAVWSMMVAAWVFLAWFVSRVADFARPSAFHRIYTLTWMYVLSWVSAVIATVYANQRGLAGGYFIFFFHAGIFLAKWISYLELFALPSKTEYANQLRSASGRASGHGSRRGTTSGEDDGEEAEEEPTESTSLLGSGQRTTFANYVRVGGDNHAVAEEEVIDPNVYGREQAWSYALPKWTWVLQLLLTAPITLIMVGPLALLTISAISQTGQDGGHPLFAYVAIAIFTTIMLTPLLPFIHRYTYHVPLFLLAVFLGTLIYNLVAFPFSDSNRLKLYYVQEVDLDTGVNSATFAGLSPFVKDVSQELPSAAGQTVSCEWHTKRRNLLSCSWEGIAPQPVEGDHPMKDWVSFNISKSTDKPQARFEVSGLNTRACRILFDTPVKNFHVAGSAYDPRFPYDAAGVNEIRLWSRTWENQWTVDVDWDEGALKGNVVCLWSDHNQPGVLPALDEAIQFLPVWAAVTKGSDGLVEGRRAFEIGNDD
Enzyme Length 955
Uniprot Accession Number Q2UU23
Absorption
Active Site ACT_SITE 220; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Glycosylation (3); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9)
Keywords Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 105,601
Kinetics
Metal Binding METAL 174; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 186; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 186; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 221; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 246; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 319; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561
Rhea ID
Cross Reference Brenda