Detail Information for IndEnz0002001832
IED ID IndEnz0002001832
Enzyme Type ID protease001832
Protein Name Vacuolar membrane protease
EC 3.4.-.-
FXNA-related family protease 1
Gene Name AGL209W
Organism Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Eremothecium Eremothecium gossypii (Yeast) (Ashbya gossypii) Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)
Enzyme Sequence MKLTKAVFRFRRTNLSTLLVITYLVITTLYVWDHFRYHFTLPSDYNYAQMLADAWLDLEIITQYPHPYASHANDKVHDYLLDRVKEITRDSMFAEISDDYGMGLRTLFRQEDAISGTKESTVVYYESSNVLARVQGRNSALDGLLLSAHYDSVPSGYGATDDGMGVVSMLAILTHYVKNQPERTLVFNFNNNQEFGLAGASAFFEHPWSKEISYVINLEGTGAGGKAVLFRTSDVSTAQVYAEAVRQQPFGNSMYQQGFYNGHIGTETDFQVYEDQGLRGWDIAFYRPRNLYHTAKDTVLYTSKQALWHMLHTALQLTDYMAINKPDMEDTSNAVYFDLFGKWFVVWSARSLFYWNCIILALFPSILAILFLVAYDMQLLKFNFWDAMLRLPVSVCLAYFCVKLFQVLVGQLNPYVFSRDYVSPILAEASMFIFMNYVILSSWERLRPLRDFKTVALVEVSMVLWIYLISVTRWLRDSDYTATGLYPFTIGYTFVSIGAIIGVFCATFKAKLNPEDDSYVGDSKVDIEQQQMLMQHQYQQHSQKHSNQHSPHHSTHHSAQHSVHHSPRQSIHQVPSSEQRQRDASETPHVIISVDHTAGHQEDSEVTPLLNTGTVAPFPKPVPERVSRKSFLRNVVTSILNYDWSIQFMVVTPWVTYFTWICLDLIMGAMNQTIQESAKGTTFVTHMALIGSLLLSLPMLPFTYKLHSFAGMLFLLLAVTTAVWTIVAPPFTESSPLKLRFLQTIDLDKNNSSSVYLYGRERTFMEPILDDIPSVTKYRCVEYAGDGVDICEYNGMPPRMFNNHHEAESDWTKIMTLEILKDDRNSTSRTPYQPITAELKINVEENRVCTLNFNSTAFKNWKQGVSPLREVVILHENPSSNVTPSFYNTAMKNGYYQDEFGNDHYRWNNGITELQLHKLDFKRGYYKIGLEWIPQLLYRGYDPATSSSEEDDALGVSVTCYWGEYDTDSITDGFATTNVPAYDELRKYSPKNIIYSSKEKGMVSVTKYVEL
Enzyme Length 1011
Uniprot Accession Number Q750Z6
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.-.-
Enzyme Function FUNCTION: May be involved in vacuolar sorting and osmoregulation. {ECO:0000250|UniProtKB:P38244}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Compositional bias (2); Glycosylation (4); Metal binding (6); Region (1); Site (1); Topological domain (10); Transmembrane (9)
Keywords Glycoprotein;Hydrolase;Membrane;Metal-binding;Metalloprotease;Protease;Reference proteome;Transmembrane;Transmembrane helix;Vacuole;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Vacuole membrane {ECO:0000250|UniProtKB:P38244}; Multi-pass membrane protein {ECO:0000255}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 115,899
Kinetics
Metal Binding METAL 149; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 161; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 161; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 194; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 219; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 293; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561
Rhea ID
Cross Reference Brenda