Detail Information for IndEnz0002001838
IED ID IndEnz0002001838
Enzyme Type ID protease001838
Protein Name Plasmepsin VIII
PbPMVIII
EC 3.4.23.-
Plasmepsin 8
Gene Name PMVIII PM8 PBANKA_1329100
Organism Plasmodium berghei (strain Anka)
Taxonomic Lineage cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Vinckeia) Plasmodium berghei Plasmodium berghei (strain Anka)
Enzyme Sequence MNKFFVFPLLLILNSIVLVKSLTENLRVSRYSKPGVSTIILKGGYINRQFIGEISIGNPPQSFKVLFDTGSTNLWIPSKNCYAKACYNKKKYDYNISKNYRISSSKNPVNIFFGTGKVQIAYATDDIHLGSIKVRNQEFGIANYMSDDPFSDMQFDGLFGLGISEDIKRKGLIYDNIPRNSSRKNVFSIYYPKSVDDNGAITFGGYDKKYIEPNSNIDWFVVSSRKYWTIKMTGIKINGLFLEVCSGNIEGYCDAVIDTGTSSIAGPQNDLILLTKLLNPVKSCQNKTLLKNFSFVFSDENGVEKEYELTSNDYIVNSFKVDPILKNPCNFAFMPINISSPNGYLYILGQVFLQKYYAIFEKDNMRIGLAKSI
Enzyme Length 373
Uniprot Accession Number A0A509AWX2
Absorption
Active Site ACT_SITE 68; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 258; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.23.-
Enzyme Function FUNCTION: During the development in the mosquito vector, plays an essential role in sporozoite egress from the oocyst and sporozoite gliding motility, which is required for the invasion of salivary glands and subsequent transmission to the host. {ECO:0000269|PubMed:28192122}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Chain (1); Domain (1); Propeptide (1); Signal peptide (1)
Keywords Aspartyl protease;Hydrolase;Protease;Reference proteome;Signal;Zymogen
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..21; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 42,148
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda