| IED ID | IndEnz0002001838 |
| Enzyme Type ID | protease001838 |
| Protein Name |
Plasmepsin VIII PbPMVIII EC 3.4.23.- Plasmepsin 8 |
| Gene Name | PMVIII PM8 PBANKA_1329100 |
| Organism | Plasmodium berghei (strain Anka) |
| Taxonomic Lineage | cellular organisms Eukaryota Sar Alveolata Apicomplexa Aconoidasida Haemosporida (haemosporidians) Plasmodiidae Plasmodium Plasmodium (Vinckeia) Plasmodium berghei Plasmodium berghei (strain Anka) |
| Enzyme Sequence | MNKFFVFPLLLILNSIVLVKSLTENLRVSRYSKPGVSTIILKGGYINRQFIGEISIGNPPQSFKVLFDTGSTNLWIPSKNCYAKACYNKKKYDYNISKNYRISSSKNPVNIFFGTGKVQIAYATDDIHLGSIKVRNQEFGIANYMSDDPFSDMQFDGLFGLGISEDIKRKGLIYDNIPRNSSRKNVFSIYYPKSVDDNGAITFGGYDKKYIEPNSNIDWFVVSSRKYWTIKMTGIKINGLFLEVCSGNIEGYCDAVIDTGTSSIAGPQNDLILLTKLLNPVKSCQNKTLLKNFSFVFSDENGVEKEYELTSNDYIVNSFKVDPILKNPCNFAFMPINISSPNGYLYILGQVFLQKYYAIFEKDNMRIGLAKSI |
| Enzyme Length | 373 |
| Uniprot Accession Number | A0A509AWX2 |
| Absorption | |
| Active Site | ACT_SITE 68; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103; ACT_SITE 258; /evidence=ECO:0000255|PROSITE-ProRule:PRU01103 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: During the development in the mosquito vector, plays an essential role in sporozoite egress from the oocyst and sporozoite gliding motility, which is required for the invasion of salivary glands and subsequent transmission to the host. {ECO:0000269|PubMed:28192122}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Domain (1); Propeptide (1); Signal peptide (1) |
| Keywords | Aspartyl protease;Hydrolase;Protease;Reference proteome;Signal;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,148 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |