| IED ID | IndEnz0002001848 |
| Enzyme Type ID | protease001848 |
| Protein Name |
Serine protease 55 EC 3.4.21.- |
| Gene Name | Prss55 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MILPSILLLVAHTLEANVECGVRPLYDSRIQYSRIIEGQEAELGEFPWQVSIQESDHHFCGGSILSEWWILTVAHCFYAQELSPTDLRVRVGTNDLTTSPVELEVTTIIRHKGFKRLNMDNDIALLLLAKPLTFNELTVPICLPLWPAPPSWHECWVAGWGVTNSTDKESMSTDLMKVPMRIIEWEECLQMFPSLTTNMLCASYGNESYDACQGDSGGPLVCTTDPGSRWYQVGIISWGKSCGKKGFPGIYTVLAKYTLWIEKIAQTEGKPLDFRGQSSSNKKKNRQNNQLSKSPALNCPQSWLLPCLLSFALLRALSNWK |
| Enzyme Length | 321 |
| Uniprot Accession Number | Q14BX2 |
| Absorption | |
| Active Site | ACT_SITE 75; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 122; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction (PubMed:30032357). {ECO:0000269|PubMed:30032357}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (1); Lipidation (1); Propeptide (1); Region (1); Sequence conflict (1); Signal peptide (1) |
| Keywords | Cell membrane;Cytoplasmic vesicle;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30032357}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:30032357}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:30032357}. Note=Mainly observed in the luminal side of seminiferous tubules and sperm acrosome. {ECO:0000269|PubMed:30032357}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..16; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11217851; 12466851; 21677750; 29563520; 32301961; 33417308; |
| Motif | |
| Gene Encoded By | |
| Mass | 36,087 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |