Detail Information for IndEnz0002001848
IED ID IndEnz0002001848
Enzyme Type ID protease001848
Protein Name Serine protease 55
EC 3.4.21.-
Gene Name Prss55
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MILPSILLLVAHTLEANVECGVRPLYDSRIQYSRIIEGQEAELGEFPWQVSIQESDHHFCGGSILSEWWILTVAHCFYAQELSPTDLRVRVGTNDLTTSPVELEVTTIIRHKGFKRLNMDNDIALLLLAKPLTFNELTVPICLPLWPAPPSWHECWVAGWGVTNSTDKESMSTDLMKVPMRIIEWEECLQMFPSLTTNMLCASYGNESYDACQGDSGGPLVCTTDPGSRWYQVGIISWGKSCGKKGFPGIYTVLAKYTLWIEKIAQTEGKPLDFRGQSSSNKKKNRQNNQLSKSPALNCPQSWLLPCLLSFALLRALSNWK
Enzyme Length 321
Uniprot Accession Number Q14BX2
Absorption
Active Site ACT_SITE 75; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 122; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 216; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction (PubMed:30032357). {ECO:0000269|PubMed:30032357}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (4); Domain (1); Glycosylation (1); Lipidation (1); Propeptide (1); Region (1); Sequence conflict (1); Signal peptide (1)
Keywords Cell membrane;Cytoplasmic vesicle;Disulfide bond;GPI-anchor;Glycoprotein;Hydrolase;Lipoprotein;Membrane;Protease;Reference proteome;Serine protease;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30032357}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:30032357}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:30032357}. Note=Mainly observed in the luminal side of seminiferous tubules and sperm acrosome. {ECO:0000269|PubMed:30032357}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..16; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11217851; 12466851; 21677750; 29563520; 32301961; 33417308;
Motif
Gene Encoded By
Mass 36,087
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda