| IED ID |
IndEnz0002001870 |
| Enzyme Type ID |
protease001870 |
| Protein Name |
Secapin-2
|
| Gene Name |
|
| Organism |
Apis mellifera (Honeybee) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Hymenoptera
Apocrita (wasps
ants
and bees)
Aculeata
Apoidea (bees)
Apidae (bumble bees and honey bees)
Apinae (honey bees)
Apini
Apis
Apis mellifera (Honeybee)
|
| Enzyme Sequence |
MKNYSKNATYLITVLLFSFVTMLLIIPSKCEAVSNDMQPLEARTADLVQQPRYIIDVPPRCPPGSKFVHKRCRVIVP |
| Enzyme Length |
77 |
| Uniprot Accession Number |
I1VC85 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Serine protease inhibitor which exhibits antifibrinolytic, antielastolytic and antimicrobial activities (By similarity). Displays antimicrobial activity against bacteria and fungi (By similarity). Likely functions in the innate immune response to microbial infection and possibly in the venom, as an antifibrinolytic agent (By similarity). Induces hyperalgesia and edema mediated by leukotrienes when injected into mice (PubMed:25017240). Does not induce hemolytic activity, mast cell degranulation, or chemotactic activity for polymorphonucleated leukocytes (PMNL) (PubMed:25017240). {ECO:0000250|UniProtKB:A0A0K1YW63, ECO:0000269|PubMed:25017240}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Disulfide bond (1); Modified residue (1); Peptide (1); Propeptide (1); Signal peptide (1) |
| Keywords |
Amidation;Antibiotic;Antimicrobial;Direct protein sequencing;Disulfide bond;Fungicide;Immunity;Innate immunity;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25017240}. |
| Modified Residue |
MOD_RES 77; /note=Proline amide; /evidence=ECO:0000269|PubMed:25017240 |
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..32; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
8,763 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|