Detail Information for IndEnz0002001877
IED ID IndEnz0002001877
Enzyme Type ID protease001877
Protein Name Secretion monitor
Gene Name secM EcolC_3560
Organism Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Enterobacteriaceae Escherichia Escherichia coli Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)
Enzyme Sequence MSGILTRWRQFGKRYFWPHLLLGMVAASLGLPALSNAAEPNAPAKATTRNHEPSAKVNFGQLALLEANTRRPNSNYSVDYWHQHAIRTVIRHLSFAMAPQTLPVAEESLPLQAQHLALLDTLSALLTQEGTPSEKGYRIDYAHFTPQAKFSTPVWISQAQGIRAGPQRLT
Enzyme Length 170
Uniprot Accession Number B1IR81
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation. {ECO:0000255|HAMAP-Rule:MF_01332}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Signal peptide (1)
Keywords Cytoplasm;Periplasm;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_01332}. Periplasm {ECO:0000255|HAMAP-Rule:MF_01332}. Note=The active form is cytosolic, while the periplasmic form is rapidly degraded, mainly by the tail-specific protease. {ECO:0000255|HAMAP-Rule:MF_01332}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..37; /evidence=ECO:0000255|HAMAP-Rule:MF_01332
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,880
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda