Detail Information for IndEnz0002001883
IED ID IndEnz0002001883
Enzyme Type ID protease001883
Protein Name Signal peptidase complex catalytic subunit SEC11
EC 3.4.21.89
Signal peptidase I
Gene Name SEC11 PGUG_03249
Organism Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Meyerozyma Meyerozyma guilliermondii (Yeast) (Candida guilliermondii) Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Enzyme Sequence MNLRQQLTQFLTMAFVFSSSFMAWKTLSVVTNSHSPVVVVLSGSMEPAFQRGDILFLWNRQRQNKVGDVVVYEIKGKDIPIVHRVLREHHNSEKQYLLTKGDNNLVDDLGLYAKKQGYLNQATDLVGTVKAYLPKVGYVTILISENMYARYALLGIMCISSLLTGE
Enzyme Length 166
Uniprot Accession Number A5DIZ8
Absorption
Active Site ACT_SITE 44; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367; ACT_SITE 83; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367; ACT_SITE 108; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:P15367
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.; EC=3.4.21.89; Evidence={ECO:0000250|UniProtKB:P15367};
DNA Binding
EC Number 3.4.21.89
Enzyme Function FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity). {ECO:0000250|UniProtKB:P15367, ECO:0000250|UniProtKB:P67812}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Erroneous gene model prediction (1); Region (1); Topological domain (2); Transmembrane (1)
Keywords Endoplasmic reticulum;Hydrolase;Membrane;Protease;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15367}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P15367}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 18,759
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda