| IED ID |
IndEnz0002001936 |
| Enzyme Type ID |
protease001936 |
| Protein Name |
Transcriptional activator II
|
| Gene Name |
cII lambdap59 |
| Organism |
Escherichia phage lambda (Bacteriophage lambda) |
| Taxonomic Lineage |
Viruses
Duplodnaviria
Heunggongvirae
Uroviricota
Caudoviricetes
Caudovirales
Siphoviridae (phages with long non-contractile tails)
Lambdavirus
Escherichia phage lambda (Bacteriophage lambda)
|
| Enzyme Sequence |
MVRANKRNEALRIESALLNKIAMLGTEKTAEAVGVDKSQISRWKRDWIPKFSMLLAVLEWGVVDDDMARLARQVAAILTNKKRPAATERSEQIQMEF |
| Enzyme Length |
97 |
| Uniprot Accession Number |
P03042 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
DNA_BIND 26..45; /note=H-T-H motif; /evidence=ECO:0000255 |
| EC Number |
|
| Enzyme Function |
FUNCTION: Acts as a transcriptional activator that allows virus to initiate a latent state. Following infection, participates, together with cIII, in activation of the Pe and Pi promoters, which are responsible for the transcription of the cI (repressor) and int (integrase) genes, respectively. Both of these gene products are required for the establishment of latency. {ECO:0000269|PubMed:19853572, ECO:0000269|PubMed:3159014, ECO:0000269|PubMed:6295882, ECO:0000269|PubMed:9218777}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); DNA binding (1); Helix (5) |
| Keywords |
3D-structure;Activator;DNA-binding;Early protein;Reference proteome;Transcription;Transcription regulation;Viral latency;Viral latency initiation and maintenance |
| Interact With |
P0AAI3 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
X-ray crystallography (3) |
| Cross Reference PDB |
1XWR;
1ZPQ;
1ZS4;
|
| Mapped Pubmed ID |
21943085;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
11,056 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|