Detail Information for IndEnz0002001962
IED ID IndEnz0002001962
Enzyme Type ID protease001962
Protein Name Subtilisin-like protease CPC735_047380
EC 3.4.21.-
Gene Name CPC735_047380
Organism Coccidioides posadasii (strain C735) (Valley fever fungus)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Onygenales incertae sedis Coccidioides Coccidioides posadasii (Valley fever fungus) Coccidioides posadasii (strain C735) (Valley fever fungus)
Enzyme Sequence MARINVVVSFLAALAVVQAAQLLNLDGQKDAVPGSYVVVMNDGLSGLDFESHVKSMAKVQKANALKRDFDNTADGVKFKYNINGWQAYSGKFDNKTIQSILDDPRVNYIEPQRTFRAFGWVTQDNAPSWGLGRISHTSRGRMDYVYDSSAGENVTVYSVDSGVDISHPEFEGRAIWGVNAADNSDVDQIGHGTHTSGTIAGKTYGVAKMAKIVAVKVLDAGGQGTNGGIIQGINWAVNHARQNNVTGKAVMNMSFGGGLSRAINEAASSAVRAGIFMVAAAGNNNEDARYTTPASARGVCAVGASTQNDLKARFSNWGPTLAVYAPGDRIWSAMPDGGRDVMRGTSMAAPHVAGVAAVLISSEKIGTDRLCERIKELSVSSIQSPGADTTDKLLYNGSGQ
Enzyme Length 400
Uniprot Accession Number C5PFR5
Absorption
Active Site ACT_SITE 160; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 191; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240; ACT_SITE 346; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU01240
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.21.-
Enzyme Function FUNCTION: Secreted subtilisin-like serine protease with keratinolytic activity that contributes to pathogenicity. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Domain (2); Glycosylation (4); Propeptide (1); Signal peptide (1)
Keywords Glycoprotein;Hydrolase;Protease;Secreted;Serine protease;Signal;Virulence;Zymogen
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 42,313
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda