IED ID |
IndEnz0002001965 |
Enzyme Type ID |
protease001965 |
Protein Name |
Cell division inhibitor SulA
|
Gene Name |
sulA SFV_0966 |
Organism |
Shigella flexneri serotype 5b (strain 8401) |
Taxonomic Lineage |
cellular organisms
Bacteria
Proteobacteria
Gammaproteobacteria
Enterobacterales
Enterobacteriaceae
Shigella
Shigella flexneri
Shigella flexneri 5
Shigella flexneri serotype 5b (strain 8401)
|
Enzyme Sequence |
MYTSGYAHRSSSFSSAASKIARVSTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQSRWQLWLTPQQKLSREWVQASGLPLTKVMQISQLSPCHTVESMVRALRTGNYSVVIGWLTDDLTEEEHAELVDAANEGNAMGFIMRPVSASSHTTRQLSGLKIHSNLYH |
Enzyme Length |
169 |
Uniprot Accession Number |
Q0T677 |
Absorption |
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Active Site |
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Activity Regulation |
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Binding Site |
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Calcium Binding |
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catalytic Activity |
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DNA Binding |
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EC Number |
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Enzyme Function |
FUNCTION: Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. {ECO:0000255|HAMAP-Rule:MF_01179}. |
Temperature Dependency |
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PH Dependency |
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Pathway |
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nucleotide Binding |
|
Features |
Chain (1); Region (2); Site (1) |
Keywords |
Cell cycle;Cell division;DNA damage;SOS response;Septation |
Interact With |
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Induction |
INDUCTION: By DNA damage, as part of the SOS response. {ECO:0000255|HAMAP-Rule:MF_01179}. |
Subcellular Location |
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Modified Residue |
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Post Translational Modification |
PTM: Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired. {ECO:0000255|HAMAP-Rule:MF_01179}. |
Signal Peptide |
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Structure 3D |
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Cross Reference PDB |
- |
Mapped Pubmed ID |
- |
Motif |
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Gene Encoded By |
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Mass |
18,861 |
Kinetics |
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Metal Binding |
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Rhea ID |
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Cross Reference Brenda |
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