| IED ID | IndEnz0002001970 |
| Enzyme Type ID | protease001970 |
| Protein Name |
Tumor protein p53-inducible nuclear protein 1 Stress-induced protein Thymus-expressed acidic protein TEAP p53-dependent damage-inducible nuclear protein 1 p53DINP1 |
| Gene Name | Trp53inp1 Sip |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MFQRLNKMFVGEVTTSSSHEPEFSEKEDDEWILVDFIDTCTGFSAEEEEEDEDIGEESSAEHTSVFSCLPTSLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDDYNSSGPRMEAQSELGTHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDCHTRQMKHRCWAVHQPCPRQYNY |
| Enzyme Length | 239 |
| Uniprot Accession Number | Q80YE2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Motif (1) |
| Keywords | Activator;Antioxidant;Apoptosis;Autophagy;Cytoplasm;Cytoplasmic vesicle;Nucleus;Reference proteome;Transcription;Transcription regulation;Tumor suppressor |
| Interact With | |
| Induction | INDUCTION: In chronic pancreatitis tissue, expression is suppressed by camostat mesilate, a serine protease inhibitor, and by Saiko-keishi-to, a herbal medicine. {ECO:0000269|PubMed:15254349}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 21965303; 27105917; 30193876; |
| Motif | MOTIF 25..37; /note=LIR |
| Gene Encoded By | |
| Mass | 26,976 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |