| IED ID | IndEnz0002001990 |
| Enzyme Type ID | protease001990 |
| Protein Name |
Collagen alpha-1 I chain Alpha-1 type I collagen |
| Gene Name | COL1A1 |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MFSFVDLRLLLLLAATALLTHGQEEGQEEGQEEDIPPVTCVQNGLRYHDRDVWKPVPCQICVCDNGNVLCDDVICDELKDCPNAKVPTDECCPVCPEGQESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEGGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPSGPPGPKGNSGEPGAPGSKGDTGAKGEPGPTGIQGPPGPAGEEGKRGARGEPGPAGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGAPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGAPGKDGVRGLTGPIGPPGPAGAPGDKGEAGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGPKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGSKGPRGETGPAGRPGEVGPPGPPGPAGEKGAPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPMGPPGLAGPPGESGREGAPGAEGSPGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPIGPVGARGPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPSGASGPAGPRGPPGSAGSPGKDGLNGLPGPIGPPGPRGRTGDAGPAGPPGPPGPPGPPGPPSGGYDLSFLPQPPQEKAHDGGRYYRADDANVVRDRDLEVDTTLKSLSQQIENIRSPEGSRKNPARTCRDLKMCHSDWKSGEYWIDPNQGCNLDAIKVFCNMETGETCVYPTQPSVAQKNWYISKNPKEKRHVWYGESMTGGFQFEYGGQGSDPADVAIQLTFLRLMSTEASQNITYHCKNSVAYMDQQTGNLKKALLLQGSNEIEIRAEGNSRFTYSVTYDGCTSHTGAWGKTVIEYKTTKTSRLPIIDVAPLDVGAPDQEFGFDVGPACFL |
| Enzyme Length | 1463 |
| Uniprot Accession Number | P02453 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Type I collagen is a member of group I collagen (fibrillar forming collagen). |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (7); Disulfide bond (5); Domain (2); Glycosylation (2); Metal binding (5); Modified residue (127); Motif (2); Propeptide (2); Region (4); Sequence conflict (9); Signal peptide (1) |
| Keywords | Calcium;Collagen;Direct protein sequencing;Disulfide bond;Extracellular matrix;Glycoprotein;Hydroxylation;Metal-binding;Phosphoprotein;Pyrrolidone carboxylic acid;Reference proteome;Repeat;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}. |
| Modified Residue | MOD_RES 162; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:4115172; MOD_RES 170; /note=Allysine; /evidence=ECO:0000269|PubMed:4115172; MOD_RES 171; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P02454; MOD_RES 189; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 192; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 195; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 204; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 207; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 210; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 225; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 240; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 246; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 255; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 261; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 264; /note=5-hydroxylysine; alternate; /evidence=ECO:0000269|PubMed:1164916; MOD_RES 270; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P02454; MOD_RES 276; /note=5-hydroxylysine; /evidence=ECO:0000255; MOD_RES 285; /note=5-hydroxylysine; /evidence=ECO:0000255; MOD_RES 288; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 291; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 297; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 306; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 312; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 333; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 342; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 345; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 372; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 375; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 387; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 393; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 402; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 408; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 411; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 426; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 429; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 435; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 438; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 450; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 459; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 474; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 480; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 489; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 495; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 504; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 513; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 522; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 528; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 534; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 543; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 546; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 555; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 564; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 570; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 582; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 591; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 600; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 603; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 621; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 639; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 645; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 651; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 657; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 663; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 669; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 681; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 690; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 702; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 714; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 717; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 723; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 729; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 738; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 750; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 756; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 771; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 777; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 786; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P02454; MOD_RES 798; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 804; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 807; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 816; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 822; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 840; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 849; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 858; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 861; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 870; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 876; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 884; /note=3-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 885; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 894; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 897; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 918; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 927; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 936; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 945; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 963; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 972; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 975; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 981; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 996; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1002; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1008; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1017; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1023; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1032; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1044; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1047; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1050; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1095; /note=5-hydroxylysine; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1107; /note=5-hydroxylysine; alternate; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1119; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1122; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1125; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1143; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P02457; MOD_RES 1158; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 1163; /note=3-hydroxyproline; /evidence=ECO:0000269|PubMed:11946479; MOD_RES 1164; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 1178; /note=3-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1179; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1181; /note=3-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1182; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1184; /note=3-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 1185; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1188; /note=4-hydroxyproline; /evidence=ECO:0000269|PubMed:25645914; MOD_RES 1191; /note=4-hydroxyproline; /evidence=ECO:0000250|UniProtKB:P11087; MOD_RES 1207; /note=Allysine; /evidence=ECO:0000269|PubMed:11946479 |
| Post Translational Modification | PTM: Contains mostly 4-hydroxyproline. Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. {ECO:0000269|PubMed:1164916, ECO:0000269|PubMed:11946479}.; PTM: Contains 3-hydroxyproline at a few sites. This modification occurs on the first proline residue in the sequence motif Gly-Pro-Hyp, where Hyp is 4-hydroxyproline. {ECO:0000269|PubMed:11946479}.; PTM: Lysine residues at the third position of the tripeptide repeating unit (G-X-Y) are 5-hydroxylated in some or all of the chains. {ECO:0000250|UniProtKB:P02457}.; PTM: O-glycosylated on hydroxylated lysine residues. The O-linked glycan consists of a Glc-Gal disaccharide. {ECO:0000250|UniProtKB:P11087}. |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12878203; |
| Motif | MOTIF 744..746; /note=Cell attachment site; /evidence=ECO:0000255; MOTIF 1092..1094; /note=Cell attachment site; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 138,938 |
| Kinetics | |
| Metal Binding | METAL 1276; /note=Calcium; /evidence=ECO:0000250; METAL 1278; /note=Calcium; /evidence=ECO:0000250; METAL 1279; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 1281; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0000250; METAL 1284; /note=Calcium; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |