Detail Information for IndEnz0002002002
IED ID IndEnz0002002002
Enzyme Type ID protease002002
Protein Name Flotillin-1
Reggie-2
REG-2
Gene Name Flot1 Reg2
Organism Rattus norvegicus (Rat)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat)
Enzyme Sequence MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAVGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA
Enzyme Length 428
Uniprot Accession Number Q9Z1E1
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Alternative sequence (2); Chain (1); Modified residue (4)
Keywords Alternative splicing;Cell membrane;Endosome;Membrane;Phosphoprotein;Reference proteome
Interact With
Induction INDUCTION: By optic nerve injury.
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75955}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome {ECO:0000250|UniProtKB:O75955}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000250|UniProtKB:O75955}. Membrane raft {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola. {ECO:0000250|UniProtKB:O08917, ECO:0000250|UniProtKB:O75955}.
Modified Residue MOD_RES 19; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 163; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 385; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 387; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:O75955
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12591123; 14581507; 15545008; 15934946; 16396496; 16785509; 16917501; 17206938; 17218121; 17482312; 17982011; 18155272; 19298817; 20600927; 20669324; 21187433; 23622064; 24349196; 24612608; 25732136; 27676653; 30452906;
Motif
Gene Encoded By
Mass 47,499
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda