| IED ID | IndEnz0002002002 |
| Enzyme Type ID | protease002002 |
| Protein Name |
Flotillin-1 Reggie-2 REG-2 |
| Gene Name | Flot1 Reg2 |
| Organism | Rattus norvegicus (Rat) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Rattus Rattus norvegicus (Rat) |
| Enzyme Sequence | MFFTCGPNEAMVVSGFCRSPPVMVAGGRVFVLPCIQQIQRISLNTLTLNVKSEKVYTRHGVPISVTGIAQVKIQGQNKEMLAAACQMFLGKTEAEIAHIALETLEGHQRAIMAHMTVEEIYKDRQKFSEQVFKVASSDLVNMGISVVSYTLKDIHDDQDYLHSLGKARTAQVQKDARIGEAEAKRDAGIREAKAKQEKVSAQCLSEIEMAKAQRDYELKKATYDIEVNTRRAQADLAYQLQVAKTKQQIEEQRVQVQVVERAQQVAVQEQEIARREKELEARVRKPAEAERYRLERLAEAEKAQLIMQAEAEAESVRMRGEAEAFAVGARARAEAEQMAKKAEAFQMYQEAAQLDMLLEKLPQVAEEISGPLTSANKITLVSSGSGTMGAAKVTGEVLDILSRLPESVERLTGVSISQVNHNKPLRTA |
| Enzyme Length | 428 |
| Uniprot Accession Number | Q9Z1E1 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (2); Chain (1); Modified residue (4) |
| Keywords | Alternative splicing;Cell membrane;Endosome;Membrane;Phosphoprotein;Reference proteome |
| Interact With | |
| Induction | INDUCTION: By optic nerve injury. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75955}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75955}. Endosome {ECO:0000250|UniProtKB:O75955}. Membrane, caveola {ECO:0000250|UniProtKB:O08917}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08917}. Melanosome {ECO:0000250|UniProtKB:O75955}. Membrane raft {ECO:0000250|UniProtKB:O75955}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Membrane-associated protein of caveola. {ECO:0000250|UniProtKB:O08917, ECO:0000250|UniProtKB:O75955}. |
| Modified Residue | MOD_RES 19; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 163; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 385; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:O75955; MOD_RES 387; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:O75955 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12591123; 14581507; 15545008; 15934946; 16396496; 16785509; 16917501; 17206938; 17218121; 17482312; 17982011; 18155272; 19298817; 20600927; 20669324; 21187433; 23622064; 24349196; 24612608; 25732136; 27676653; 30452906; |
| Motif | |
| Gene Encoded By | |
| Mass | 47,499 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |