| IED ID | IndEnz0002002038 |
| Enzyme Type ID | protease002038 |
| Protein Name |
Heat shock 70 kDa protein 1 Heat shock cognate 70 kDa protein 1 Heat shock cognate protein 70-1 AtHsc70-1 Heat shock protein 70-1 AtHsp70-1 Protein EARLY-RESPONSIVE TO DEHYDRATION 2 |
| Gene Name | HSP70-1 ERD2 HSC70-1 MED37_4 MED37E At5g02500 T22P11.90 |
| Organism | Arabidopsis thaliana (Mouse-ear cress) |
| Taxonomic Lineage | cellular organisms Eukaryota Viridiplantae Streptophyta Streptophytina Embryophyta Tracheophyta Euphyllophyta Spermatophyta Magnoliopsida Mesangiospermae eudicotyledons Gunneridae Pentapetalae rosids malvids Brassicales Brassicaceae Camelineae Arabidopsis Arabidopsis thaliana (Mouse-ear cress) |
| Enzyme Sequence | MSGKGEGPAIGIDLGTTYSCVGVWQHDRVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPVNTVFDAKRLIGRRFSDSSVQSDMKLWPFKIQAGPADKPMIYVEYKGEEKEFAAEEISSMVLIKMREIAEAYLGVTIKNAVVTVPAYFNDSQRQATKDAGVIAGLNVMRIINEPTAAAIAYGLDKKATSVGEKNVLIFDLGGGTFDVSLLTIEEGIFEVKATAGDTHLGGEDFDNRMVNHFVQEFKRKSKKDITGNPRALRRLRTSCERAKRTLSSTAQTTIEIDSLYEGIDFYSTITRARFEELNMDLFRKCMEPVEKCLRDAKMDKSTVHDVVLVGGSTRIPKVQQLLQDFFNGKELCKSINPDEAVAYGAAVQGAILSGEGNEKVQDLLLLDVTPLSLGLETAGGVMTTLIPRNTTIPTKKEQVFSTYSDNQPGVLIQVYEGERARTKDNNLLGKFELSGIPPAPRGVPQITVCFDIDANGILNVSAEDKTTGQKNKITITNDKGRLSKDEIEKMVQEAEKYKSEDEEHKKKVEAKNALENYAYNMRNTIQDEKIGEKLPAADKKKIEDSIEQAIQWLEGNQLAEADEFEDKMKELESICNPIIAKMYQGAGGEAGGPGASGMDDDAPPASGGAGPKIEEVD |
| Enzyme Length | 651 |
| Uniprot Accession Number | P22953 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: In cooperation with other chaperones, Hsp70s are key components that facilitate folding of de novo synthesized proteins, assist translocation of precursor proteins into organelles, and are responsible for degradation of damaged protein under stress conditions (Probable). Probably involved in defense response. Chaperone involved in protein targeting to chloroplasts. May cooperate with SGT1 and HSP90 in R gene-mediated resistance towards the oomycete Hyaloperonospora parasitica (downy mildew). Plays a role with WPP-domain proteins in facilitating WIT1 nuclear envelope targeting (PubMed:12805626, PubMed:18065690, PubMed:19617588). Modulates stomatal aperture in response to various environmental conditions and physiological responses to the hormone abscisic acid (ABA) (PubMed:21586649). {ECO:0000269|PubMed:12805626, ECO:0000269|PubMed:18065690, ECO:0000269|PubMed:19617588, ECO:0000269|PubMed:21586649, ECO:0000305|PubMed:11402207}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Initiator methionine (1); Modified residue (1); Region (1); Sequence conflict (6) |
| Keywords | ATP-binding;Acetylation;Alternative splicing;Chaperone;Cytoplasm;Nucleotide-binding;Nucleus;Plant defense;Reference proteome;Stress response;Transcription;Transcription regulation |
| Interact With | Q9SUT5 |
| Induction | INDUCTION: Induced by heat shock and cold (PubMed:11402207). Induced by dehydration stress and abscisic acid (ABA) (PubMed:8075396). Up-regulated by viral infection (PubMed:15805473). {ECO:0000269|PubMed:11402207, ECO:0000269|PubMed:15805473, ECO:0000269|PubMed:8075396}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28004282}. Nucleus {ECO:0000269|PubMed:28004282}. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0007744|PubMed:22223895 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10344193; 10446203; 10508612; 11179422; 12433921; 12482876; 12887064; 12954627; 14505352; 14617066; 14655047; 15028209; 15276459; 15496452; 15763661; 15821981; 16247729; 16287169; 16502469; 17151019; 17317660; 17360592; 17432890; 17644812; 18324730; 18431481; 18538804; 18650403; 18775970; 19000166; 19443614; 19453450; 21139434; 21166475; 21798377; 22010978; 22115780; 22771433; 23615222; 25874349; 26830344; 27539741; 28627464; 30426513; 30833711; 31327714; 31933409; 32344669; 32573848; 33325122; 33506954; 7651336; 7984243; 8706819; 8804399; 9437862; 9750105; 9914526; |
| Motif | |
| Gene Encoded By | |
| Mass | 71,358 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.6.4.10; |