Detail Information for IndEnz0002002261
IED ID IndEnz0002002261
Enzyme Type ID protease002261
Protein Name Leech factor Xa inhibitor
Lefaxin
Fragments
Gene Name
Organism Haementeria depressa (Leech)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Spiralia Lophotrochozoa Annelida Clitellata Hirudinea (leeches) Rhynchobdellida Glossiphoniidae Haementeria Haementeria depressa (Leech)
Enzyme Sequence FDVPEPFKWVDHFFYEKLDEQHKGLFFAFFDWGKGPDYWGKDTISLSQEQVDAKFELDLEYGIFYGNGETIENPSENGDLQGIFFSWGSE
Enzyme Length 90
Uniprot Accession Number P86681
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Potent anticoagulant inhibiting the amidolytic activity of factor Xa (F10) (Ki=4nM) and reducing its ability to activate prothrombin (F2) in the prothrombinase complex (EC(50)=40nM). {ECO:0000269|PubMed:10595640}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Non-adjacent residues (4); Non-terminal residue (1)
Keywords Blood coagulation;Direct protein sequencing;Hemostasis;Protease inhibitor;Secreted
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 10,575
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda