Detail Information for IndEnz0002002263
IED ID IndEnz0002002263
Enzyme Type ID protease002263
Protein Name Zinc metalloprotease mde10
EC 3.4.24.-
Meiotically up-regulated gene 139 protein
Sporulation protein mde10
Gene Name mde10 mug139 SPAC17A5.04c
Organism Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota Taphrinomycotina Schizosaccharomycetes Schizosaccharomycetales Schizosaccharomycetaceae Schizosaccharomyces Schizosaccharomyces pombe (Fission yeast) Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Enzyme Sequence MRLVLLFSCVLAVSSYAEIILAHSDENLLSRTKNNLSKWNENRLYDYGSKSTMSLPVSSLFPALQTLWIGVVADCSYVTHFTSRMEAKKHIFQEFEGVSTLYEDSFNINVQIHSLILPSAHDCSANVVDRPEISMSPRISIEEKLEIFSKWKYESPGNNVFEAISPHERESFPSEPQVSVLFTSSVKRSPHGVSWFATICSETHIENEWHVGPLSVVSAYPNDRLVVAHEIGHILGLIHDCNKKSCGDHSEACCPLSSSLCDAQELYIMNPSNSYTYANLRFSDCSILQLHSLVEKKYVSLSCLSKPSEKSVLRLGTCGNGIVEDGEECDCGEDCENNPCCDGKTCKLTKGSLCDDQQDACCYQCHFKNAGTLCRQSTNPCDKPEFCTGISSKCPVDENWDDGRICQDSLGMGSCASGVCTSASRQCKKLTNFSSLSCHSDSCKVSCQNEDGTCFISAKDYIDGTRCRGGLCYNGVCVPIEGSSASWSKQPSLFCASGTMLISLAVIAWFFW
Enzyme Length 512
Uniprot Accession Number O13766
Absorption
Active Site ACT_SITE 230; /evidence="ECO:0000255|PROSITE-ProRule:PRU00276, ECO:0000255|PROSITE-ProRule:PRU10095"
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: Has a role in the development of the spore envelope. {ECO:0000269|PubMed:14871934, ECO:0000269|PubMed:16303567}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (2); Domain (2); Glycosylation (2); Metal binding (3); Mutagenesis (1); Signal peptide (1)
Keywords Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Meiosis;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Sporulation;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum. Spore wall. Note=Endoplasmic reticulum during meiosis. Located at the spore rim at the end of meiosis.
Modified Residue
Post Translational Modification PTM: Glycosylated. {ECO:0000269|PubMed:14871934}.
Signal Peptide SIGNAL 1..15; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 12618370; 12845604; 20473289; 23697806; 23738021; 28410370;
Motif
Gene Encoded By
Mass 56,440
Kinetics
Metal Binding METAL 229; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 233; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 239; /note=Zinc; catalytic; /evidence=ECO:0000305
Rhea ID
Cross Reference Brenda