Detail Information for IndEnz0002002297
IED ID IndEnz0002002297
Enzyme Type ID protease002297
Protein Name RNA-directed RNA polymerase L
Protein L
EC 2.7.7.48
Large structural protein
Replicase
Transcriptase
Gene Name L
Organism Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Taxonomic Lineage Viruses Riboviria Orthornavirae Negarnaviricota Polyploviricotina Ellioviricetes Bunyavirales Peribunyaviridae Orthobunyavirus Schmallenberg orthobunyavirus Schmallenberg virus (SBV) Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)
Enzyme Sequence METYKINIFRDRINQCRSAEEAKDIVADLLMARHDYFGREVCYYLDIEFRQDVPAYDILLEFLPAGTAFNIRNCTPDNFIIHNGKLYIIDYKVSTDHAYGQKTYEKYTQIFGDALSELPFDFEVVIIRADPLRDTIHVNSNQFLEIFGPLNINLDFTWFFNLRSLIYEKYKDDDRFLEIVNQGEFTMTGPWIDEDTPELYSHPVFLEFYDSLDEMAKLTFHESMTFDATRGEKWNQNLQKVINRYGNDYNIFVKEAAAGIFRCEGNYPKPNHDEITIGWNQMVQRVSTERNLTQDVSKQKPSIHFIWGQPDETSNATTPKLIKIAKALQNISGESTYISAFRALGMLMDFSENTALYEAHTSKLKSMARQTSKRIDTKLEPIKIGTATIYWEQQFKLDTEIMNTKDKSHLLKDFLGIGGHVQFSKKTIDDLDTDKPTILDFNKKEVIDFCKFQYENVKKILSGDNNLERIGCYLEEYGANIASCSKDTWDQINQIGKSNYWACIKDFSVLMKNMLAVSQYNRHNTFRVVCCANNNLFGFVMPSSDIKAKRSTLVYFLAVLHSTPQNVMHHGALHATFKTGSKYLSISKGMRLDKERCQRIVSSPGLFMLTTLMFAGDNPTLNLTDVMNFTFHTSLSITKAMLSLTEPSRYMIMNSLAISSHVRDYIAEKFGPYTKTSFSVVMANLIKRGCYMAYNQRDKVDMRNICLTDYEITQKGVRDNRDLSSIWFEGYVSLKEYINQIYLPFYFNSKGLHEKHHVMIDLAKTILDIERDQRLNIPGIWSTTPRKQTANLNITIYAVAKNLIMDTARHNYIRSRIENTNNLNRSICTISTFTSSKSCIKVGDFEKEKSSATKKAADCMSKEIKKYTIANPEFVDEELLNATIRHSRYEDLKKAIPNYIDIMSTKVFDSLYQKIKRKEIDDKPTVYHILSAMKNHTDFKFTFFNKGQKTAKDREIFVGEFEAKMCLYLVERISKERCKLNPDEMISEPGDSKLKKLEELAESEIRFTAATMKQIKERYLAEMGEASHMIAYKPHSVKIEINADMSKWSAQDVLFKYFWLFALDPALYLQEKERILYFLCNYMQKKLILPDEMLCSILDQRIKHEDDIIYEMTNGLSQNWVNIKRNWLQGNLNYTSSYLHSCSMNVYKDILKRAATLLEGEVLVNSMVHSDDNHTSIVMIQDKLDDDIVIEFSAKLFEKICLTFGNQANMKKTYITNFIKEFVSLFNIYGEPFSVYGRFILTSVGDCAFLGPYEDVASRLSATQTAIKHGAPPSLAWTAIALTQWITHSTYNMLPGQINDPTSSLPSHDRFELPIELCGLINSELPTIAIAGLEADNLSYLVRLSKRMSPIHLCREPIQHQYENIHTWDISKLTQCDIFRLKLLRYMTLDSTMSSDDGMGETSEMRSRSLLTPRKFTTASSLSRLHSYADYQKTIQDQQKIEELFEYFIANPQLLVTKGETCEEFCMSVLFRYNSRKFKESLSIQNPAQLFIEQVLFANKPMIDYTSIHDRLFGIQDDPNINDATCIIGKKTFVETYQQIKIDVEKFTLDVEDIKTIYSFCIMNDPILVACANNLLISIQGVEMQRLGMTCCYMPEIKSLKVIYHSPALVLRAYVTDNYEQKGMEPDEMRRDIYHLEEFIEKTKLRTNMQGRIANNEIKLMKRDLKFEVQELTKFYQICYEYVKSTEHKIKIFILPKKAYTPIDFCSLVTGNLISDNKWMVVHYLKQITVPAKKAQIATSIDLEIQIAYECFRLIAHFADMFLNDDSKKAYINAIINTYTYKDVQVSSLYKKIKNSRLRSKIIPLLYHLGDLQQIDVDRFDAEKAEEQITWNNWQTSREFTTGPIDLSIKGYGRSIRIVGEDNKLTAAEMQLSRVRSDIVSRHGQALLNKPHGLKLEKMEPVTDLNPKLWYIAYQLREKKRYHYGVFSTSYIEEHNSRIEASRIRKTNKWIPVCPIAISKQSSDGKPSLAKIPMLNIGEIKFTKLQIAVDDHAMIRKAPFSKMVFFDGPPIQSGGIDIGKLMKNQNILNLRLDNIQSITLLDLCRIFSCRGSKVDQDAFEFLSDEPLDEDVIDELDSSPALVVSYTKKSTKSNSFKNVIVRALIRECDIFEDIMDITDDGFTSDSNLEVLENLTWILNMLATNQWSTELLACIHMCLYRNEMDHIYHNFQVPEIFVDNPISLNVKWDEVIMFLNILRDRDYKFEPWVSILNHSLTKAIEYAYKKMEEERKQKSTGINKFLKGKKMGGRSKFDFQ
Enzyme Length 2254
Uniprot Accession Number H2AM11
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
DNA Binding
EC Number 2.7.7.48
Enzyme Function FUNCTION: RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Domain (1)
Keywords Hydrolase;Nucleotide-binding;Nucleotidyltransferase;Protease;RNA-directed RNA polymerase;Thiol protease;Transferase;Ubl conjugation pathway;Viral RNA replication;Virion
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Virion {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 261,027
Kinetics
Metal Binding
Rhea ID RHEA:21248
Cross Reference Brenda