Detail Information for IndEnz0002002303
IED ID IndEnz0002002303
Enzyme Type ID protease002303
Protein Name m-AAA protease-interacting protein 1, mitochondrial
Matrix AAA peptidase-interacting protein 1
Gene Name Maip1
Organism Mus musculus (Mouse)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse)
Enzyme Sequence MALAARLLPLPLLSRPLPGPVTRLRTLGSTEVRLTLTEICCLCRRRLGSSAAPIPRYTRAWTSPALRSWSSRRSLLGRVEHPPALASLPASPSRSYSTEEQPQQRQRTRMIILGFSNPINWVRTRIYAFLIWAYFDKEFSIAEFSEGAKQAFAYVSKLLSQCKFDLLEELVAKEVLQILKEKVTSLSDNHKNALAADIDDIVYTSTGDISIYYDEKGRKFVNILMCFWYLTSANIPSESLSGANVFQVKLGDQSVETKQLLSASYEFQREFTQGVKPDWTIARIEHSKLLE
Enzyme Length 291
Uniprot Accession Number Q8BHE8
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). {ECO:0000250|UniProtKB:Q8WWC4}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Erroneous initiation (1); Transit peptide (1)
Keywords Mitochondrion;Reference proteome;Transit peptide
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8WWC4}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10725249; 11217851; 12466851; 21267068; 21677750; 33220177;
Motif
Gene Encoded By
Mass 32,985
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda