Detail Information for IndEnz0002002351
IED ID IndEnz0002002351
Enzyme Type ID protease002351
Protein Name Methionine aminopeptidase 2-1
MAP 2-1
MetAP 2-1
EC 3.4.11.18
Peptidase M
Gene Name BDCG_02379
Organism Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Ajellomycetaceae Blastomyces Ajellomyces dermatitidis (Blastomyces dermatitidis) Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)
Enzyme Sequence MAAQVTPELANLNSKPEGGAPPKQVPVKDVPENEDVESDDDNEGDQGAGEPGSTGAAKKKKKKKPKKKKKGGPKVQTEPPRVILSSIFPNNDYPVGELVEYKDDNAYRTTNEEKRYLDRMNNDFLSEYRYAAEVHRQVRQYAQKTIKPGQTLTEIAEGIEDSVRALTGHDGLTEGDNLLGGIAFPTGVNLNHCAAHYSPNAGNKMVLQYEDVMKVDFGVHINGRIVDSAFTVAFDPVYDNLLAAVKDATNTGIREAGIDVRMSDIGAAIQETMESYEVEIKGTTYPVKPIRNLNGHTIGQFEIHGGKNGKSVPIVKGGDQSKMEEGEVYAIETFGSTGRGYVRDDMETSHYAKVPDAPNVPLRLSSAKNLLNVITKNFGTLPFCRRYLDRLGQDKYLLGLNNLVANGIVDAYPPLCDIKGSYTAQFEHTILLRPNIKEVISRGYDY
Enzyme Length 446
Uniprot Accession Number C5GCN0
Absorption
Active Site
Activity Regulation
Binding Site BINDING 196; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; BINDING 304; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_03175};
DNA Binding
EC Number 3.4.11.18
Enzyme Function FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_03175}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Compositional bias (1); Metal binding (7); Region (1)
Keywords Aminopeptidase;Cytoplasm;Hydrolase;Metal-binding;Protease;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 49,025
Kinetics
Metal Binding METAL 216; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 227; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 227; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 296; /note=Divalent metal cation 2; catalytic; via tele nitrogen; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 332; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 427; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 427; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Rhea ID
Cross Reference Brenda