Detail Information for IndEnz0002002360
IED ID IndEnz0002002360
Enzyme Type ID protease002360
Protein Name Methionine aminopeptidase 2-1
MAP 2-1
MetAP 2-1
EC 3.4.11.18
Peptidase M
Gene Name ATEG_10146
Organism Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Circumdati Aspergillus terreus Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Enzyme Sequence MGSKTPDGHRQSPDASNSSELKPASPNPKPSQNGSQSADLDRGVVGEDDDDDDENEEVGVITTNAEKKKKRKKSKKKNKKSKSGAAPATQQTTPPRVPLSTLFPSGYPVGELVPYENTARTTDEESQYNSRLWDEDLLTDYRQAAEIHRQVRQYAQAELIKPGASLQSIAEGIEDGVRALCGHQGLDTGDALKAGMGFPTGLCLNNIAAHWTPNPGGKDVILEKSDVLKVDFGVHINGRIVDSAFTVAFDHTYDNLLTAVKEATNTGIMVHVFLDDLVGSEVMESYEVDLAGKTIPVKAIRNITGHDILRYNIHGGKQIPFIKNNNPDKMEEGEVFAIETFGSTGKGVLDDDIGIYGYGRNANVPGSHLRLASAKSLLKTIDANFGSLVFCRRYLERLGVKSYHLGMKNLIDNGIVESYAPLVDVKGSYTAQFEHTILLHSGGKEVISRGEDY
Enzyme Length 453
Uniprot Accession Number Q0C838
Absorption
Active Site
Activity Regulation
Binding Site BINDING 210; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; BINDING 314; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_03175};
DNA Binding
EC Number 3.4.11.18
Enzyme Function FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_03175}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Compositional bias (4); Metal binding (7); Region (1)
Keywords Aminopeptidase;Cytoplasm;Hydrolase;Metal-binding;Protease;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 49,298
Kinetics
Metal Binding METAL 231; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 242; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 242; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 306; /note=Divalent metal cation 2; catalytic; via tele nitrogen; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 339; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 434; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 434; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Rhea ID
Cross Reference Brenda