Detail Information for IndEnz0002002376
IED ID IndEnz0002002376
Enzyme Type ID protease002376
Protein Name Methionine aminopeptidase 2-2
MAP 2-2
MetAP 2-2
EC 3.4.11.18
Peptidase M
Gene Name MGYG_01859
Organism Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Nannizzia Arthroderma gypseum (Microsporum gypseum) Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893) (Microsporum gypseum)
Enzyme Sequence MAAQAAPELAKLDLNKNTGSAEASTVPASGSDKDDAENEGDSDDDRDDEQTGGSAEVNAEKKKKKKRPKKKKKTAKVQSVPPRIPLTTLFPNNSFPEGEIVEYLNENSYRTTNEEKRHLDRMNNDFLAEYRQAAEIHRQVRQYAQKELIKPGATLTDIAEGIEDGVRHLTGHLGLEEGDSLVAGMGFPTGLNINHCAAHYSPNAGNKVVLQHGDVMKVDFGVHVNGRIVDSAFTVAFDPVFDPLLTAVKEATNTGIKEAGIDVRMSDIGAAIQETMESYELELNGTSYPIKAIRNLNGHTIGQYEIHGGVNGKSVPIVKGGDQTKMEEGETYAIETFGSTGKGYVRDDMETSHYAKVPSAPSVPLRLTSAKNLYSLINKNFGTLPFCRRYLDRLGQEKYLLGLNNLVSSGLVDAYPPLCDVKGSYTAQFEHTILLRPNVKEVISRGDDY
Enzyme Length 449
Uniprot Accession Number E5R3Z8
Absorption
Active Site
Activity Regulation
Binding Site BINDING 199; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; BINDING 307; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_03175};
DNA Binding
EC Number 3.4.11.18
Enzyme Function FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_03175}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Compositional bias (2); Metal binding (7); Region (1)
Keywords Aminopeptidase;Cytoplasm;Hydrolase;Metal-binding;Protease;Reference proteome
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 49,131
Kinetics
Metal Binding METAL 219; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 230; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 230; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 299; /note=Divalent metal cation 2; catalytic; via tele nitrogen; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 335; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 430; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 430; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Rhea ID
Cross Reference Brenda