Detail Information for IndEnz0002002404
IED ID IndEnz0002002404
Enzyme Type ID protease002404
Protein Name Methionine aminopeptidase
MAP
MetAP
EC 3.4.11.18
Peptidase M
Gene Name map AF_1840
Organism Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Taxonomic Lineage cellular organisms Archaea Euryarchaeota Archaeoglobi Archaeoglobales Archaeoglobaceae Archaeoglobus Archaeoglobus fulgidus Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
Enzyme Sequence MDDEVREKLIEAGKILKQAVNEAAEKIAPGVKILEVAEFVENRIIELGAKPAFPANISINSDAAHFTPKKNDERTFKEGDVVKLDVGAHIDGYIADMAVTVDLGDNTELVKAAKEALEAAMEVVRAGVSVSEIGKAIEDAITNYGFKPIVNLTGHGLLPYLNHAPPSIYNYATEKGVTLEEGMVVAIEPFATNGVGKVGERGECEIYSLLNPRPVRMKMAREILKEVEENYKTLPFAKRWLKKAPDIIISKLAREGVLRAYPVLTEVSGGLVSQWEHTLIVEDGGATITTK
Enzyme Length 291
Uniprot Accession Number O28438
Absorption
Active Site
Activity Regulation
Binding Site BINDING 65; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; BINDING 163; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_01975
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_01975};
DNA Binding
EC Number 3.4.11.18
Enzyme Function FUNCTION: Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_01975}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Metal binding (7)
Keywords Aminopeptidase;Hydrolase;Metal-binding;Protease;Reference proteome
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 31,691
Kinetics
Metal Binding METAL 85; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 96; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 96; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 155; /note=Divalent metal cation 2; catalytic; via tele nitrogen; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 188; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 276; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_01975; METAL 276; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_01975
Rhea ID
Cross Reference Brenda