Detail Information for IndEnz0002002407
IED ID IndEnz0002002407
Enzyme Type ID protease002407
Protein Name Methionine aminopeptidase 2
MAP 2
MetAP 2
EC 3.4.11.18
Peptidase M
Gene Name BC1G_04189
Organism Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Leotiomycetes Helotiales Sclerotiniaceae Botrytis Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea) Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Enzyme Sequence MAAQVTDALKNLKVKDPNAVVESAAEAKANGNAQPEAEAEDSDDDDEEPVNGEGAGEGGAKKKRKRKKKPKKKAGANPKVQSSPPRVLLSNLFPSGEYPVGEEVEYRDENNYRTTSEEKRYLDRMNNDFLQEYRQGAEIHRQVRQYAKANIKPGQTLTEIAEGIEDSVRALTGHPGLEEGDNIKGGVAFPTGVNLDHIAAHYSPNAGNKTVLAYENVMKVDFGVHINGRIVDSAFTIAFDPMYDNLLEAVKQATNTGIKEAGIDARLGEIGEHIQETMESYEVEIKGQTYQVKPIRNLNGHDILQWKIHGGKSVPIVKSNDQTKMEEGEVFAIETFGSTGNGYVRDDLECSHYAKVADAPNVPLRIASAGKLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNALVSHGIVQDYPPLVDKKGSYTAQFEHTIVLRPNCKEVISRGDDY
Enzyme Length 448
Uniprot Accession Number A6RTU0
Absorption
Active Site
Activity Regulation
Binding Site BINDING 201; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; BINDING 309; /note=Substrate; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.; EC=3.4.11.18; Evidence={ECO:0000255|HAMAP-Rule:MF_03175};
DNA Binding
EC Number 3.4.11.18
Enzyme Function FUNCTION: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). {ECO:0000255|HAMAP-Rule:MF_03175}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Binding site (2); Chain (1); Compositional bias (2); Metal binding (7); Region (1)
Keywords Aminopeptidase;Cytoplasm;Hydrolase;Metal-binding;Protease
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03175}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 49,382
Kinetics
Metal Binding METAL 221; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 232; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 232; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 301; /note=Divalent metal cation 2; catalytic; via tele nitrogen; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 334; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 429; /note=Divalent metal cation 1; /evidence=ECO:0000255|HAMAP-Rule:MF_03175; METAL 429; /note=Divalent metal cation 2; catalytic; /evidence=ECO:0000255|HAMAP-Rule:MF_03175
Rhea ID
Cross Reference Brenda