| IED ID | IndEnz0002002410 |
| Enzyme Type ID | protease002410 |
| Protein Name |
Calpain small subunit 2 CSS2 Calcium-dependent protease small subunit 2 |
| Gene Name | CAPNS2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS |
| Enzyme Length | 248 |
| Uniprot Accession Number | Q96L46 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | CA_BIND 88..99; /note="1"; /evidence="ECO:0000250|UniProtKB:Q64537"; CA_BIND 132..143; /note="2"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448"; CA_BIND 162..173; /note="3"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448" |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Calcium binding (3); Chain (1); Domain (4); Metal binding (13); Sequence conflict (1) |
| Keywords | Calcium;Cell membrane;Cytoplasm;Membrane;Metal-binding;Reference proteome;Repeat |
| Interact With | Q8N2F6-2; Q96DZ9-2; Q96HP4; Q96KR7; P45877; Q8WWY3; Q13671 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10639123; 10830966; 12843408; 17608959; 19913121; 20628086; 21030783; 21670566; 21864727; 23035980; 23390828; 7698360; 9228946; |
| Motif | |
| Gene Encoded By | |
| Mass | 27,660 |
| Kinetics | |
| Metal Binding | METAL 89; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 92; /note=Calcium 1; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 94; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 117; /note=Calcium 4; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 132; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 134; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 136; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 138; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 143; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 162; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 164; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 166; /note=Calcium 3; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 205; /note=Calcium 4; /evidence=ECO:0000250|UniProtKB:Q64537 |
| Rhea ID | |
| Cross Reference Brenda |