Detail Information for IndEnz0002002410
IED ID IndEnz0002002410
Enzyme Type ID protease002410
Protein Name Calpain small subunit 2
CSS2
Calcium-dependent protease small subunit 2
Gene Name CAPNS2
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEPPPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFSLDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQAAGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKEWLQLTMYS
Enzyme Length 248
Uniprot Accession Number Q96L46
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding CA_BIND 88..99; /note="1"; /evidence="ECO:0000250|UniProtKB:Q64537"; CA_BIND 132..143; /note="2"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448"; CA_BIND 162..173; /note="3"; /evidence="ECO:0000250|UniProtKB:Q64537, ECO:0000255|PROSITE-ProRule:PRU00448"
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Calcium binding (3); Chain (1); Domain (4); Metal binding (13); Sequence conflict (1)
Keywords Calcium;Cell membrane;Cytoplasm;Membrane;Metal-binding;Reference proteome;Repeat
Interact With Q8N2F6-2; Q96DZ9-2; Q96HP4; Q96KR7; P45877; Q8WWY3; Q13671
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon calcium binding. {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10639123; 10830966; 12843408; 17608959; 19913121; 20628086; 21030783; 21670566; 21864727; 23035980; 23390828; 7698360; 9228946;
Motif
Gene Encoded By
Mass 27,660
Kinetics
Metal Binding METAL 89; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 92; /note=Calcium 1; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 94; /note=Calcium 1; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 117; /note=Calcium 4; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 132; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 134; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 136; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 138; /note=Calcium 2; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 143; /note=Calcium 2; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 162; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 164; /note=Calcium 3; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 166; /note=Calcium 3; via carbonyl oxygen; /evidence=ECO:0000250|UniProtKB:Q64537; METAL 205; /note=Calcium 4; /evidence=ECO:0000250|UniProtKB:Q64537
Rhea ID
Cross Reference Brenda