Detail Information for IndEnz0002002424
IED ID IndEnz0002002424
Enzyme Type ID protease002424
Protein Name Mitochondrial presequence protease
EC 3.4.24.-
Gene Name cym-1 B13M13.120 NCU01272
Organism Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Enzyme Sequence MLRNATKGAARRAVTELSQYPKPGEKLHGFTLLRSKHVPELELTALHLQHDKTGAEHLHIARDDSNNVFSIGFKTNPPDDTGVPHILEHTTLCGSQKYPIRDPFFKMLPRTLSNFMNAFTASDHTFYPFATTNAQDFKNLMSVYLDATLHPLLKETDFTQEGWRIGPENPQALVAAEGNAKPEDRKLVFKGVVYNEMKGQMSDAAYLFWIRFQDHIFPDIHNSGGDPQKITDLTYQQLKKFHADHYHPSNAKVFTYGDMPLADHLKEIGAQLDVFEKIRADVAHHSPIDLSSGPREVKLYGPIDPLVDANKQFKTSVSWVLGETNNVVESFSLALISALLMDGYGSPLYKGLIESGLGTDWSPNTGYDSSGKLGIFSIGLSGVQEEDVPKVKAKVQEILRSMRDKGFERSKIDGYLHQLELGLKHKTANFGMSLLHRLKPKWFVGVDPFDSLAWNDTIAAFETELAKGGYLEGLIDKYLINDNTLSFTMAPSPTFSQELAQEEETRLSTKISEVVKAAGSEEEARAALEARELKLLAEQSKTNTEDLGCLPSVHVKDIPRQKDSVILRHDNTARVKTQWHEAPTNGLTYFRAINQLENLPDELRSLIPLFTDSIMRLGTKDMTMEQLEDLIKLKTGGVSVGYHSASHPTDFTRATEGLMFSGMALDRHVPTMFDLLRKLVVETDFDSPQAAQQIRQLLQASADGVVNDIASSGHAYARRAAESGLTWDSFLKEQVSGLSQVKLVTSLASRPESDPLEDVIAKLKQIQQFALAGNLRTAITCDSGSVSDNAKALLNFVNSLPSEAVTFPSRGPPNFTRDIKTFYPLPYQVYYGALALPTASYTASVNAPLQILSQLLTHKHLHHEIREKGGAYGGGSYARPLDGIFGFYSYRDPNPVNTLKIMRNAGQWAVDKEWTDRDLEDAKISVFQGVDAPKAVNEEGMAQFLYGITDEMKQKRREELLDVTKDQVREVAQEYVVKALNNGSERVVFLGEKRDWVDKSWAVKEMDINGST
Enzyme Length 1012
Uniprot Accession Number Q7S7C0
Absorption
Active Site ACT_SITE 88; /note=Proton acceptor; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.4.24.-
Enzyme Function FUNCTION: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Metal binding (3)
Keywords Hydrolase;Metal-binding;Metalloprotease;Mitochondrion;Protease;Reference proteome;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 112,825
Kinetics
Metal Binding METAL 85; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 89; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 196; /note=Zinc; catalytic; /evidence=ECO:0000250
Rhea ID
Cross Reference Brenda