| IED ID | IndEnz0002002424 |
| Enzyme Type ID | protease002424 |
| Protein Name |
Mitochondrial presequence protease EC 3.4.24.- |
| Gene Name | cym-1 B13M13.120 NCU01272 |
| Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
| Enzyme Sequence | MLRNATKGAARRAVTELSQYPKPGEKLHGFTLLRSKHVPELELTALHLQHDKTGAEHLHIARDDSNNVFSIGFKTNPPDDTGVPHILEHTTLCGSQKYPIRDPFFKMLPRTLSNFMNAFTASDHTFYPFATTNAQDFKNLMSVYLDATLHPLLKETDFTQEGWRIGPENPQALVAAEGNAKPEDRKLVFKGVVYNEMKGQMSDAAYLFWIRFQDHIFPDIHNSGGDPQKITDLTYQQLKKFHADHYHPSNAKVFTYGDMPLADHLKEIGAQLDVFEKIRADVAHHSPIDLSSGPREVKLYGPIDPLVDANKQFKTSVSWVLGETNNVVESFSLALISALLMDGYGSPLYKGLIESGLGTDWSPNTGYDSSGKLGIFSIGLSGVQEEDVPKVKAKVQEILRSMRDKGFERSKIDGYLHQLELGLKHKTANFGMSLLHRLKPKWFVGVDPFDSLAWNDTIAAFETELAKGGYLEGLIDKYLINDNTLSFTMAPSPTFSQELAQEEETRLSTKISEVVKAAGSEEEARAALEARELKLLAEQSKTNTEDLGCLPSVHVKDIPRQKDSVILRHDNTARVKTQWHEAPTNGLTYFRAINQLENLPDELRSLIPLFTDSIMRLGTKDMTMEQLEDLIKLKTGGVSVGYHSASHPTDFTRATEGLMFSGMALDRHVPTMFDLLRKLVVETDFDSPQAAQQIRQLLQASADGVVNDIASSGHAYARRAAESGLTWDSFLKEQVSGLSQVKLVTSLASRPESDPLEDVIAKLKQIQQFALAGNLRTAITCDSGSVSDNAKALLNFVNSLPSEAVTFPSRGPPNFTRDIKTFYPLPYQVYYGALALPTASYTASVNAPLQILSQLLTHKHLHHEIREKGGAYGGGSYARPLDGIFGFYSYRDPNPVNTLKIMRNAGQWAVDKEWTDRDLEDAKISVFQGVDAPKAVNEEGMAQFLYGITDEMKQKRREELLDVTKDQVREVAQEYVVKALNNGSERVVFLGEKRDWVDKSWAVKEMDINGST |
| Enzyme Length | 1012 |
| Uniprot Accession Number | Q7S7C0 |
| Absorption | |
| Active Site | ACT_SITE 88; /note=Proton acceptor; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.24.- |
| Enzyme Function | FUNCTION: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Metal binding (3) |
| Keywords | Hydrolase;Metal-binding;Metalloprotease;Mitochondrion;Protease;Reference proteome;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 112,825 |
| Kinetics | |
| Metal Binding | METAL 85; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 89; /note=Zinc; catalytic; /evidence=ECO:0000250; METAL 196; /note=Zinc; catalytic; /evidence=ECO:0000250 |
| Rhea ID | |
| Cross Reference Brenda |