| IED ID | IndEnz0002002428 |
| Enzyme Type ID | protease002428 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | ddi-1 NCU05292 |
| Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
| Enzyme Sequence | MQITIAIQDTTGDDQDFLSLQVFPDMTLETLRNSIQAETSHHPSTQHLYHNGNLITDNSKTLTQLNVTDGDMLALHVRETQRATAVPESQQGRPAAPPQQDPEFLRLQFLANPALRAEVERTAPDLAAAINDPQRWAQLFRERYDREQRERAERHRIIQQLNEDPFNPEAQARIEEIIRQERVTENLQTAMEHNPEVFGTVHMLYLDVEVNGAKVKALVDSGAQATIMSPDIAEACGIMRLVDKRYGGIAKGVGTAKIIGRVHTAPVKIGSLFLPCSFTVMEGKNVDMLLGLDMLKRYQACIDLAKNALVIQGEEIPFLGEADIPKATEEALQDEPTIEGPGGTTIGQRTGAVSGPGTAQHRQGQAGPSTAAQPGPSAPAPAPASASAPAPRAPQARSFPREHIEQLVALGADEQKAIRALEATDGNVEYAASLIFEGF |
| Enzyme Length | 439 |
| Uniprot Accession Number | Q7S906 |
| Absorption | |
| Active Site | ACT_SITE 220; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (2); Domain (2); Region (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 47,770 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |