IED ID | IndEnz0002002428 |
Enzyme Type ID | protease002428 |
Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
Gene Name | ddi-1 NCU05292 |
Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Sordariomycetidae Sordariales Sordariaceae Neurospora Neurospora crassa Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
Enzyme Sequence | MQITIAIQDTTGDDQDFLSLQVFPDMTLETLRNSIQAETSHHPSTQHLYHNGNLITDNSKTLTQLNVTDGDMLALHVRETQRATAVPESQQGRPAAPPQQDPEFLRLQFLANPALRAEVERTAPDLAAAINDPQRWAQLFRERYDREQRERAERHRIIQQLNEDPFNPEAQARIEEIIRQERVTENLQTAMEHNPEVFGTVHMLYLDVEVNGAKVKALVDSGAQATIMSPDIAEACGIMRLVDKRYGGIAKGVGTAKIIGRVHTAPVKIGSLFLPCSFTVMEGKNVDMLLGLDMLKRYQACIDLAKNALVIQGEEIPFLGEADIPKATEEALQDEPTIEGPGGTTIGQRTGAVSGPGTAQHRQGQAGPSTAAQPGPSAPAPAPASASAPAPRAPQARSFPREHIEQLVALGADEQKAIRALEATDGNVEYAASLIFEGF |
Enzyme Length | 439 |
Uniprot Accession Number | Q7S906 |
Absorption | |
Active Site | ACT_SITE 220; /evidence=ECO:0000305 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | 3.4.23.- |
Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (1); Chain (1); Compositional bias (2); Domain (2); Region (2) |
Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 47,770 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |