| IED ID | IndEnz0002002431 |
| Enzyme Type ID | protease002431 |
| Protein Name |
DNA damage-inducible protein 1 EC 3.4.23.- |
| Gene Name | ddi1 AN6741 |
| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Nidulantes Emericella nidulans (Aspergillus nidulans) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Enzyme Sequence | MTIELLKSIVESETSIPPSSQRLVYNQQLLGDDSKTLEQVGIGEGDMLGVHVTLRGGAPSVQGQARPTGIGGTSGASHSQQIQQRRQQQINPDPEMIRLHILGDPRVRDAVRQRNPELADVAHDPHRFREVLLTQQRLESQREAEKEARIAMLNADPFNPENQKEIEEIIRQNAVTENLHNAMEHHPESFGRVTMLYIPVEVNGHKLNAFVDSGAQVTIMSPDCATACNIMRLVDSRYGGIAKGVGTANILGRVHSAQIKIGDMFLPCSFTVMEGKHIDLLLGLDMLRRHQACIDLRRGALVIQDQAVPFLGEADIPKHLLEEFEDEPVIKGADGAEVGARTGAVTHQAGGSTPAPGPSSAANATASSSRPAAVHRPSPRWPEASIAKITELGFTREEATRALEAANGDLDGAIGFLI |
| Enzyme Length | 418 |
| Uniprot Accession Number | Q5AY89 |
| Absorption | |
| Active Site | ACT_SITE 212; /evidence=ECO:0000305 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.23.- |
| Enzyme Function | FUNCTION: Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. {ECO:0000250|UniProtKB:I7HUG0, ECO:0000250|UniProtKB:P40087}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Compositional bias (2); Domain (2); Erroneous initiation (2); Region (2) |
| Keywords | Aspartyl protease;Cytoplasm;Hydrolase;Protease;Protein transport;Reference proteome;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,295 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |