IED ID | IndEnz0002002434 |
Enzyme Type ID | protease002434 |
Protein Name |
Onchocystatin OV17 Cysteine proteinase inhibitor OV7 |
Gene Name | |
Organism | Onchocerca volvulus |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Spirurina Spiruromorpha Filarioidea Onchocercidae Onchocerca Onchocerca volvulus |
Enzyme Sequence | MLTIKDGTLLIHLLLFSVVALVQLQGAKSARAKNPSKMESKTGENQDRPVLLGGWEDRDPKDEEILELLPSILMKVNEQSNDEYHLMPIKLLKVSSQVVAGVKYKMDVQVARSQCKKSSNEKVDLTKCKKLEGHPEKVMTLEVWEKPWENFMRVEILGTKEV |
Enzyme Length | 162 |
Uniprot Accession Number | P22085 |
Absorption | |
Active Site | |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | |
DNA Binding | |
EC Number | |
Enzyme Function | FUNCTION: Cysteine protease inhibitor which inhibits members of the peptidase C1 family (PubMed:1512269, PubMed:12704112). In the human host, inhibits CTSL/cathepsin L and CTSS/cathepsin S and to a lesser extent CTSB/cathepsin B which may cause defects in antigen processing and thereby impair antigen-driven T cell proliferation (PubMed:12704112). {ECO:0000269|PubMed:12704112, ECO:0000269|PubMed:1512269}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Chain (1); Disulfide bond (1); Motif (1); Region (1); Signal peptide (1); Site (1) |
Keywords | Disulfide bond;Protease inhibitor;Reference proteome;Signal;Thiol protease inhibitor |
Interact With | |
Induction | |
Subcellular Location | |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..32; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | MOTIF 97..101; /note=Secondary area of contact; /evidence=ECO:0000305 |
Gene Encoded By | |
Mass | 18,415 |
Kinetics | |
Metal Binding | |
Rhea ID | |
Cross Reference Brenda |