| IED ID | IndEnz0002002440 |
| Enzyme Type ID | protease002440 |
| Protein Name |
Glutamyl endopeptidase EC 3.4.21.19 Glutamate-specific endopeptidase GSE |
| Gene Name | blaSE mpr BLi00340 BL01804 |
| Organism | Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) |
| Taxonomic Lineage | cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Bacillaceae Bacillus Bacillus subtilis group Bacillus licheniformis Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46) |
| Enzyme Sequence | MVSKKSVKRGLITGLIGISIYSLGMHPAQAAPSPHTPVSSDPSYKAETSVTYDPNIKSDQYGLYSKAFTGTGKVNETKEKAEKKSPAKAPYSIKSVIGSDDRTRVTNTTAYPYRAIVHISSSIGSCTGWMIGPKTVATAGHCIYDTSSGSFAGTATVSPGRNGTSYPYGSVKSTRYFIPSGWRSGNTNYDYGAIELSEPIGNTVGYFGYSYTTSSLVGTTVTISGYPGDKTAGTQWQHSGPIAISETYKLQYAMDTYGGQSGSPVFEQSSSRTNCSGPCSLAVHTNGVYGGSSYNRGTRITKEVFDNLTNWKNSAQ |
| Enzyme Length | 316 |
| Uniprot Accession Number | P80057 |
| Absorption | |
| Active Site | ACT_SITE 141; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083; ACT_SITE 261; /note=Charge relay system; /evidence=ECO:0000255|PROSITE-ProRule:PRU10083 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential cleavage: Glu-|-Xaa, Asp-|-Xaa.; EC=3.4.21.19; Evidence={ECO:0000255|PROSITE-ProRule:PRU10083}; |
| DNA Binding | |
| EC Number | 3.4.21.19 |
| Enzyme Function | FUNCTION: Specific for hydrolysis of peptide bonds on the carboxyl side of acidic amino acid residues, with a strong preference for Glu. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (2); Propeptide (1); Signal peptide (1) |
| Keywords | Direct protein sequencing;Disulfide bond;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..30; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 33,611 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |