Detail Information for IndEnz0002002442
IED ID IndEnz0002002442
Enzyme Type ID protease002442
Protein Name Anosmin-1
Adhesion molecule-like X-linked
Kallmann syndrome protein
Gene Name ANOS1 ADMLX KAL KAL1 KALIG1
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPHHYKPSPERY
Enzyme Length 680
Uniprot Accession Number P23352
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number
Enzyme Function FUNCTION: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19696444}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Disulfide bond (5); Domain (5); Glycosylation (6); Natural variant (19); Region (1); Sequence conflict (6); Signal peptide (1)
Keywords 3D-structure;Cell adhesion;Cell membrane;Chemotaxis;Disease variant;Disulfide bond;Glycoprotein;Heparin-binding;Hypogonadotropic hypogonadism;Kallmann syndrome;Membrane;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal
Interact With P11362; P61601; Q9UMX0
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8842728}; Peripheral membrane protein {ECO:0000269|PubMed:8842728}. Secreted {ECO:0000269|PubMed:8842728}. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space.
Modified Residue
Post Translational Modification PTM: N-glycosylated. {ECO:0000269|PubMed:8842728}.; PTM: May be proteolytically cleaved at the cell surface and released from the cell surface. {ECO:0000269|PubMed:8842728}.
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000255
Structure 3D X-ray crystallography (1)
Cross Reference PDB 1ZLG;
Mapped Pubmed ID 11463336; 12050219; 12627230; 15004876; 15324302; 15548653; 15636431; 15863029; 16597617; 16764984; 16876430; 17603054; 18160472; 18463157; 18682503; 18723471; 18985070; 19734936; 19844165; 20117945; 20219326; 20362962; 20734064; 21351529; 21497178; 21682876; 21717404; 22801565; 23189990; 23357298; 23410897; 23533228; 23721716; 24002956; 24189182; 24232061; 24732674; 25060050; 25300141; 25300351; 25662897; 25726327; 25892360; 26051373; 26278626; 26375424; 27184500; 28780519; 28854193; 29211946; 29222041; 31377880; 31669640; 34062169; 9730987;
Motif
Gene Encoded By
Mass 76,112
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda