| IED ID | IndEnz0002002442 |
| Enzyme Type ID | protease002442 |
| Protein Name |
Anosmin-1 Adhesion molecule-like X-linked Kallmann syndrome protein |
| Gene Name | ANOS1 ADMLX KAL KAL1 KALIG1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MVPGVPGAVLTLCLWLAASSGCLAAGPGAAAARRLDESLSAGSVQRARCASRCLSLQITRISAFFQHFQNNGSLVWCQNHKQCSKCLEPCKESGDLRKHQCQSFCEPLFPKKSYECLTSCEFLKYILLVKQGDCPAPEKASGFAAACVESCEVDNECSGVKKCCSNGCGHTCQVPKTLYKGVPLKPRKELRFTELQSGQLEVKWSSKFNISIEPVIYVVQRRWNYGIHPSEDDATHWQTVAQTTDERVQLTDIRPSRWYQFRVAAVNVHGTRGFTAPSKHFRSSKDPSAPPAPANLRLANSTVNSDGSVTVTIVWDLPEEPDIPVHHYKVFWSWMVSSKSLVPTKKKRRKTTDGFQNSVILEKLQPDCDYVVELQAITYWGQTRLKSAKVSLHFTSTHATNNKEQLVKTRKGGIQTQLPFQRRRPTRPLEVGAPFYQDGQLQVKVYWKKTEDPTVNRYHVRWFPEACAHNRTTGSEASSGMTHENYIILQDLSFSCKYKVTVQPIRPKSHSKAEAVFFTTPPCSALKGKSHKPVGCLGEAGHVLSKVLAKPENLSASFIVQDVNITGHFSWKMAKANLYQPMTGFQVTWAEVTTESRQNSLPNSIISQSQILPSDHYVLTVPNLRPSTLYRLEVQVLTPGGEGPATIKTFRTPELPPSSAHRSHLKHRHPHHYKPSPERY |
| Enzyme Length | 680 |
| Uniprot Accession Number | P23352 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Has a dual branch-promoting and guidance activity, which may play an important role in the patterning of mitral and tufted cell collaterals to the olfactory cortex (By similarity). Chemoattractant for fetal olfactory epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19696444}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (5); Domain (5); Glycosylation (6); Natural variant (19); Region (1); Sequence conflict (6); Signal peptide (1) |
| Keywords | 3D-structure;Cell adhesion;Cell membrane;Chemotaxis;Disease variant;Disulfide bond;Glycoprotein;Heparin-binding;Hypogonadotropic hypogonadism;Kallmann syndrome;Membrane;Protease inhibitor;Reference proteome;Repeat;Secreted;Serine protease inhibitor;Signal |
| Interact With | P11362; P61601; Q9UMX0 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8842728}; Peripheral membrane protein {ECO:0000269|PubMed:8842728}. Secreted {ECO:0000269|PubMed:8842728}. Note=Proteolytic cleavage may release it from the cell surface into the extracellular space. |
| Modified Residue | |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:8842728}.; PTM: May be proteolytically cleaved at the cell surface and released from the cell surface. {ECO:0000269|PubMed:8842728}. |
| Signal Peptide | SIGNAL 1..24; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 1ZLG; |
| Mapped Pubmed ID | 11463336; 12050219; 12627230; 15004876; 15324302; 15548653; 15636431; 15863029; 16597617; 16764984; 16876430; 17603054; 18160472; 18463157; 18682503; 18723471; 18985070; 19734936; 19844165; 20117945; 20219326; 20362962; 20734064; 21351529; 21497178; 21682876; 21717404; 22801565; 23189990; 23357298; 23410897; 23533228; 23721716; 24002956; 24189182; 24232061; 24732674; 25060050; 25300141; 25300351; 25662897; 25726327; 25892360; 26051373; 26278626; 26375424; 27184500; 28780519; 28854193; 29211946; 29222041; 31377880; 31669640; 34062169; 9730987; |
| Motif | |
| Gene Encoded By | |
| Mass | 76,112 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |