| IED ID |
IndEnz0002002446 |
| Enzyme Type ID |
protease002446 |
| Protein Name |
Hepatocyte growth factor
Hepatopoietin-A
Scatter factor
SF
Cleaved into: Hepatocyte growth factor alpha chain; Hepatocyte growth factor beta chain
|
| Gene Name |
HGF HPTA |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MWVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKTKKVNTADQCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLYENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSESPWCFTTDPNIRVGYCSQIPNCDMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNMEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNLDHPVISCAKTKQLRVVNGIPTRTNIGWMVSLRYRNKHICGGSLIKESWVLTARQCFPSRDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFVRVAYYAKWIHKIILTYKVPQS |
| Enzyme Length |
728 |
| Uniprot Accession Number |
P14210 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. {ECO:0000269|PubMed:15167892, ECO:0000269|PubMed:20624990}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (7); Beta strand (33); Chain (2); Disulfide bond (19); Domain (6); Glycosylation (5); Helix (10); Modified residue (1); Mutagenesis (1); Natural variant (2); Sequence conflict (15); Signal peptide (1); Turn (8) |
| Keywords |
3D-structure;Alternative splicing;Deafness;Direct protein sequencing;Disulfide bond;Glycoprotein;Growth factor;Kringle;Non-syndromic deafness;Pyrrolidone carboxylic acid;Reference proteome;Repeat;Serine protease homolog;Signal |
| Interact With |
Q6UY14-3; Itself; P50222; P08581; P16056; Itself; P08581 |
| Induction |
|
| Subcellular Location |
|
| Modified Residue |
MOD_RES 32; /note=Pyrrolidone carboxylic acid; /evidence=ECO:0000269|PubMed:1826837 |
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..31; /evidence=ECO:0000269|PubMed:1826837 |
| Structure 3D |
NMR spectroscopy (1); Electron microscopy (5); X-ray crystallography (29) |
| Cross Reference PDB |
1BHT;
1GMN;
1GMO;
1GP9;
1NK1;
1SHY;
1SI5;
2HGF;
2QJ2;
3HMS;
3HMT;
3HN4;
3MKP;
3SP8;
4D3C;
4K3J;
4O3T;
4O3U;
5COE;
5CP9;
5CS1;
5CS3;
5CS5;
5CS9;
5CSQ;
5CT1;
5CT2;
5CT3;
7MO7;
7MO8;
7MO9;
7MOA;
7MOB;
7OCL;
7OCM;
|
| Mapped Pubmed ID |
10521801;
10618718;
10648629;
10753869;
10871282;
11104795;
11146548;
11278729;
11323411;
11564764;
11597998;
11741535;
11781826;
11799124;
11803465;
11821397;
11836782;
11839685;
11867177;
11894096;
11909963;
11928807;
11929792;
11943656;
11960372;
11994287;
11999653;
12006644;
12051906;
12124772;
12138161;
12147692;
12151078;
12151314;
12163032;
12168776;
12184921;
12201209;
12209727;
12233882;
12244174;
12368906;
12372819;
12374695;
12379223;
12393863;
12413766;
12456016;
12475979;
12493396;
12524084;
12551915;
12619035;
12645668;
12682635;
12686592;
12694198;
12695295;
12707786;
12713878;
12726861;
12732844;
12757411;
12766170;
12792760;
12812389;
12817761;
12821940;
12837293;
12847110;
12865405;
12875981;
12879228;
12883672;
12918110;
12932865;
14500382;
14512973;
14519655;
14524531;
14555767;
14612533;
14647442;
14672920;
14684163;
14688531;
14694016;
14697967;
14699503;
14704632;
14764801;
14983012;
14989981;
15019814;
15059978;
15064106;
15087580;
15112327;
15116091;
15120936;
15123609;
15127882;
15153617;
15156160;
15172968;
15191880;
15192042;
15203188;
15218027;
15226629;
15229174;
15239259;
15240510;
15241561;
15250830;
15287857;
15292253;
15301554;
15314156;
15324701;
15334679;
15359093;
15474099;
15492846;
15502712;
15504551;
15504940;
15505094;
15525877;
15528455;
15537870;
15590419;
15602080;
15608673;
15613483;
15659325;
15678502;
15713485;
15760460;
15770726;
15777839;
15781227;
15792801;
15824471;
15828871;
15834429;
15838885;
15875782;
15880501;
15913806;
16000876;
16006475;
16014626;
16019534;
16039997;
16052207;
16083876;
16102116;
16113677;
16136515;
16144920;
16205632;
16216128;
16227611;
16236134;
16246197;
16279944;
16303761;
16338307;
16403414;
16407846;
16469801;
16498238;
16505200;
16537482;
1655790;
16606674;
16621453;
16627020;
16647110;
16648972;
16651617;
16677802;
16684952;
16709175;
16709855;
16723436;
16728464;
16740060;
16782899;
16790083;
16807517;
16849525;
16859527;
16861928;
16902162;
16951184;
17062664;
17099727;
17143015;
17154373;
17178341;
17203235;
17215249;
17244893;
17262819;
17307814;
17322284;
17325667;
17372204;
17384084;
17435158;
17452892;
17464544;
17483355;
17518673;
17520376;
17572495;
17574028;
17593080;
17597814;
17599773;
17625116;
17626784;
17702746;
17804794;
17872495;
17876341;
17881575;
17901400;
17907155;
17911637;
17921114;
17942284;
17967179;
17971014;
17973092;
17981115;
17981731;
17992475;
18003605;
18004740;
18021988;
18024311;
18053801;
18059365;
18065658;
18091351;
18096875;
18164961;
18234969;
18251163;
18264938;
18274928;
18291418;
18319552;
18326526;
18422749;
18424072;
1846706;
18491380;
18495663;
18501120;
18504429;
18539758;
18564920;
18569024;
18585357;
18606717;
18628208;
18691255;
18754654;
18779368;
18787186;
18789327;
18812567;
18813782;
18819921;
18829560;
18844210;
1885621;
18956268;
18973760;
18979225;
18992144;
19010854;
19020551;
19020737;
19021063;
19021204;
19023030;
19047046;
19050584;
19060265;
19109251;
19114710;
19118941;
19124156;
19127344;
19154948;
19184985;
19185846;
19188684;
19223201;
19223316;
19230022;
19249525;
19260711;
19281086;
19281453;
19318497;
19321255;
19386985;
19389925;
19411071;
19416273;
19423096;
19423540;
19426716;
19452723;
19468262;
19470725;
19471602;
19478261;
19508152;
19515220;
19521120;
19526316;
19533745;
19542190;
19553700;
19563076;
19615360;
19625133;
19628037;
19644473;
19661216;
19661350;
19692652;
19713535;
19720831;
19749787;
19797611;
19805105;
19808973;
19817696;
19832844;
19858036;
19881549;
19888551;
19913121;
19934279;
19939200;
19956874;
19961885;
20005573;
20007454;
20015050;
20019837;
20021260;
20061986;
20066125;
20122738;
20129249;
20131016;
20145145;
20150826;
20177149;
20178463;
20185166;
20200025;
20200161;
20203323;
20372801;
20406964;
20424473;
20438785;
20483455;
20484018;
20493732;
20519660;
20522708;
20533298;
20534479;
20568106;
20580899;
20584902;
20628086;
20639469;
20661229;
20670691;
20699604;
20713702;
20728428;
20802513;
20819464;
20819770;
20852387;
20930612;
20937841;
20977675;
20980460;
21042281;
21082280;
21102635;
21131364;
21131996;
21168200;
21183732;
21187969;
21226996;
21234230;
21317208;
21342325;
21360495;
21362320;
21368164;
21372320;
21376809;
21395178;
21396819;
21411099;
21423210;
21427651;
21440951;
21447729;
21459729;
21486864;
21520010;
21561997;
21572126;
21643812;
21655918;
21658389;
21664574;
21668414;
21703533;
21723061;
21750433;
21777671;
21779929;
21782801;
21784852;
21827948;
21872356;
21897747;
21899661;
21918175;
21920521;
21922134;
21926191;
21932108;
21976531;
22003120;
22040972;
22127603;
22136730;
22172411;
22178588;
22188813;
22203985;
22242160;
22252121;
22276607;
22282252;
22286923;
22318499;
22354962;
22392903;
22413835;
22426494;
22435662;
22441736;
22447520;
22495710;
22509107;
22588880;
22629140;
22641068;
22675553;
22689693;
22722904;
22730814;
22741575;
22744972;
22749438;
22763439;
22771249;
22788978;
22802291;
22802530;
22843899;
22848710;
22850551;
22851691;
22854048;
22876972;
22892737;
22897854;
22915589;
22936342;
22953646;
22989111;
22996389;
23045285;
23047829;
23049908;
23053181;
23081981;
23086340;
23094709;
23123275;
23134111;
23148778;
23154434;
23212923;
23273597;
23288153;
23296269;
23303910;
23314853;
23320110;
23333382;
23359207;
23386689;
23402812;
23431957;
23484149;
23498810;
23499762;
23532890;
23532910;
23536720;
23549785;
23555662;
23585864;
23640497;
23657814;
23667593;
23701640;
23737134;
23749170;
23773083;
23882082;
23898085;
23911532;
23924923;
23967200;
24018067;
24025166;
24052949;
24055447;
24099107;
24118504;
24126105;
24142532;
24160245;
24218051;
24233399;
24258345;
24259426;
24326130;
24327573;
24366484;
24416191;
24426773;
24434899;
24480479;
24518591;
24562934;
24595237;
24609899;
24634221;
24673557;
24692544;
24700742;
24743777;
24766640;
24780821;
24797571;
24800946;
24810547;
24814316;
24828152;
24859116;
24865428;
24914205;
24937142;
24939420;
24952592;
24959005;
24969882;
24970050;
25022754;
25029565;
25057941;
25064731;
25101856;
25148209;
25162020;
25198505;
25212607;
25234944;
25241761;
25244939;
25248999;
25338331;
25351134;
25380300;
25416956;
25502629;
25504327;
25510828;
25539852;
25550581;
25552591;
25592281;
25643632;
25660117;
25690371;
25714612;
25735481;
25775951;
25793303;
25816892;
25835956;
25844809;
25873747;
25885021;
25940417;
25973105;
26025956;
26071245;
26081218;
26090463;
26097553;
26099202;
26122834;
26135603;
26141862;
26165838;
26181364;
26254225;
26282167;
26310485;
26327776;
26332121;
26335595;
26381405;
26400297;
26518250;
26527860;
26577828;
26676563;
26722560;
26790028;
26798059;
26822708;
26857230;
26876216;
26892517;
26934743;
26987019;
27094128;
27143995;
27175600;
27196782;
27224506;
27245142;
27316827;
27342109;
27374174;
27423724;
27488639;
27552115;
27573644;
27683052;
27706656;
27718226;
27779808;
27809600;
27893712;
27918718;
27922668;
27930387;
27936146;
28013036;
28076931;
28077582;
28131876;
28151481;
28314274;
28341789;
28358369;
28364348;
28447719;
28475003;
28476806;
28559461;
28573382;
28595915;
28621236;
28652056;
28653669;
28738343;
28739717;
28765324;
28766361;
28819999;
28826691;
28831645;
28837064;
28864680;
28895412;
28978320;
29133945;
29134462;
29203124;
29227979;
29238047;
29382231;
29433373;
29609131;
29674709;
29781036;
29855336;
29886319;
29913557;
29917165;
29993037;
30056064;
30089804;
30090230;
30108016;
30108175;
30136190;
30186533;
30191983;
30309648;
30400772;
30404949;
30514177;
30569179;
30592626;
30642077;
30646583;
30650495;
30786811;
30886866;
30898885;
30929159;
30934578;
30964610;
31097475;
31100425;
31104010;
31148267;
31161784;
31221203;
31254927;
31339210;
31414268;
31506927;
31519421;
31533461;
31740519;
31810304;
31906916;
31940916;
32063608;
32188473;
32202143;
32203220;
32320127;
32416690;
32770199;
32788873;
32827692;
32946618;
32976979;
32996054;
33114380;
33155201;
33212946;
33233528;
33451139;
33493531;
33648801;
33670243;
33705609;
33731699;
33760164;
33976695;
34210960;
34475057;
34502141;
34526445;
34615471;
34624218;
34789086;
34969762;
6457647;
7509446;
7513258;
7651534;
7708691;
7731718;
7854452;
7854453;
8054685;
8197126;
8208547;
8302603;
8346233;
8467233;
8621622;
8657148;
8668165;
8703035;
8906793;
9038378;
9045658;
9070211;
9094433;
9140397;
9346890;
9417118;
9440692;
9886295;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
83,134 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|