| IED ID | IndEnz0002002504 |
| Enzyme Type ID | protease002504 |
| Protein Name |
Serine/threonine-protein kinase LMTK2 EC 2.7.11.1 Apoptosis-associated tyrosine kinase 2 Brain-enriched kinase hBREK CDK5/p35-regulated kinase CPRK Kinase/phosphatase/inhibitor 2 Lemur tyrosine kinase 2 Serine/threonine-protein kinase KPI-2 |
| Gene Name | LMTK2 AATYK2 BREK KIAA1079 KPI2 LMR2 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD |
| Enzyme Length | 1503 |
| Uniprot Accession Number | Q8IWU2 |
| Absorption | |
| Active Site | ACT_SITE 265; /note="Proton acceptor"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028" |
| Activity Regulation | |
| Binding Site | BINDING 168; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CATALYTIC ACTIVITY: Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| DNA Binding | |
| EC Number | 2.7.11.1 |
| Enzyme Function | FUNCTION: Phosphorylates PPP1C, phosphorylase b and CFTR. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | NP_BIND 143..151; /note=ATP; /evidence=ECO:0000255|PROSITE-ProRule:PRU00159 |
| Features | Active site (1); Binding site (1); Chain (1); Compositional bias (7); Domain (1); Erroneous initiation (1); Modified residue (11); Natural variant (13); Nucleotide binding (1); Region (7); Sequence conflict (3); Topological domain (3); Transmembrane (2) |
| Keywords | ATP-binding;Kinase;Membrane;Nucleotide-binding;Phosphoprotein;Reference proteome;Serine/threonine-protein kinase;Transferase;Transmembrane;Transmembrane helix |
| Interact With | P36873; P41236 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:23114966}; Multi-pass membrane protein {ECO:0000269|PubMed:23114966}. |
| Modified Residue | MOD_RES 805; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 806; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 886; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 1107; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 1305; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 1307; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 1308; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 1310; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 1450; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 1496; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6; MOD_RES 1497; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q3TYD6 |
| Post Translational Modification | PTM: Autophosphorylated. Phosphorylated (By similarity). {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 12832520; 16428298; 18029400; 18264097; 18429820; 18794092; 19318432; 19366831; 19423541; 19549807; 19855435; 19866473; 19900942; 19902474; 20450899; 20460480; 20564319; 20569440; 20878950; 21071540; 21382349; 22220831; 24366813; 24727471; 26008968; 26496610; 26559041; 28040547; 31395338; 31722712; 31748522; |
| Motif | |
| Gene Encoded By | |
| Mass | 164,900 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:17989; RHEA:46608 |
| Cross Reference Brenda |