| IED ID | IndEnz0002002521 |
| Enzyme Type ID | protease002521 |
| Protein Name |
Maritimacin EC 3.4.-.- Thermotoga bacteriocin |
| Gene Name | TM_0785 |
| Organism | Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
| Taxonomic Lineage | cellular organisms Bacteria Thermotogae Thermotogae Thermotogales Thermotogaceae Thermotoga Thermotoga maritima Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) |
| Enzyme Sequence | MEFLKRSFAPLTEKQWQEIDNRAREIFKTQLYGRKFVDVEGPYGWEYAAHPLGEVEVLSDENEVVKWGLRKSLPLIELRATFTLDLWELDNLERGKPNVDLSSLEETVRKVAEFEDEVIFRGCEKSGVKGLLSFEERKIECGSTPKDLLEAIVRALSIFSKDGIEGPYTLVINTDRWINFLKEEAGHYPLEKRVEECLRGGKIITTPRIEDALVVSERGGDFKLILGQDLSIGYEDREKDAVRLFITETFTFQVVNPEALILLKF |
| Enzyme Length | 265 |
| Uniprot Accession Number | Q9WZP2 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Activated by calcium and cobalt. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.-.- |
| Enzyme Function | FUNCTION: Protease that exhibits activity toward chymotrypsin and trypsin substrates. May have antibacterial activity. |
| Temperature Dependency | BIOPHYSICOCHEMICAL PROPERTIES: Temperature dependence: Optimum temperature is 90-93 degrees Celsius. {ECO:0000269|PubMed:11210524, ECO:0000269|PubMed:9872409}; |
| PH Dependency | BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 7.1. {ECO:0000269|PubMed:11210524, ECO:0000269|PubMed:9872409}; |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (12); Chain (1); Frameshift (1); Helix (10); Turn (1) |
| Keywords | 3D-structure;Antibiotic;Antimicrobial;Bacteriocin;Calcium;Cobalt;Direct protein sequencing;Hydrolase;Protease;Reference proteome;Secreted |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | Electron microscopy (3); X-ray crystallography (1) |
| Cross Reference PDB | 3DKT; 6WKV; 7K5W; 7KQ5; |
| Mapped Pubmed ID | 19172747; 32961724; 33953921; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,478 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 1.16.3.1;3.4.21.1; |