| IED ID | IndEnz0002002581 |
| Enzyme Type ID | protease002581 |
| Protein Name |
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 homolog EC 3.4.22.- Paracaspase |
| Gene Name | Malt1 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MSLWGQPLQASPPLAVRQPPTASSGPSTSPPAGATLNRLPEPLLRRLSESLDRAPEGRGWRQLAELAGSRGRLRLSGLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQALEHTEVLPLLNPPGLKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPYGNSSELVFNTVHVKDAGFYVCRVNNSSTFEFSQWSQLDVCDVAEVTDSFQGSMDGISESRLQICVEPRSQRLVPGSMLLLQCVAIGSPMPHYQWFKDESPLTHETKKHYTVPYVDIEHEGTYWCHVYNDRDSQDSKKAEVTIGRTDEAVECTEDELNNLGHPDNKEQTGQPLAKDKVALLIGNMSYWEHPKLKAPLVDVYELTNLLRQLDFKVVSLLDLTEYEMCNAVDEFLLLLDKGVYGLLYYAGHGYENFGNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDALKVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCHLTKGRQALEIRSSLSEKRALTDPVQGAPCSAEALVRNLQWAKAHELPESMCLKFQCGVHIQLGFAAEFSNVMIIYTSIVHKPPEIIMCDAYVTDFPLDLDIDPKHANKGTPEETGSYLVSKDLPKHCLYTRLSSLQKLKEHLIFTVCLSYQYSGLEDTVEEKQEVNVGKPLIAKLDMHRGLGRKTCFQACRMPDEPYHSSTSTSAGAGHFHSSQDSFHDVYHSHLGNADSGMPPDRCHCSRTPHTFISNYPPHHYCQFGRSNVPVETTDEMPFSFSDRLMISEN |
| Enzyme Length | 832 |
| Uniprot Accession Number | Q2TBA3 |
| Absorption | |
| Active Site | ACT_SITE 423; /evidence=ECO:0000255; ACT_SITE 472; /evidence=ECO:0000255 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.22.- |
| Enzyme Function | FUNCTION: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation (By similarity). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (PubMed:25282160). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (By similarity). {ECO:0000250|UniProtKB:Q9UDY8, ECO:0000269|PubMed:25282160}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Alternative sequence (1); Beta strand (19); Chain (1); Compositional bias (1); Disulfide bond (2); Domain (3); Helix (11); Initiator methionine (1); Modified residue (2); Motif (1); Region (2); Sequence conflict (3); Turn (5) |
| Keywords | 3D-structure;Acetylation;Alternative splicing;Cytoplasm;Disulfide bond;Hydrolase;Immunity;Immunoglobulin domain;Nucleus;Phosphoprotein;Protease;Reference proteome;Repeat;Ubl conjugation pathway |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UDY8}. Nucleus {ECO:0000250|UniProtKB:Q9UDY8}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity). {ECO:0000250|UniProtKB:Q9UDY8}. |
| Modified Residue | MOD_RES 2; /note=N-acetylserine; /evidence=ECO:0000250|UniProtKB:Q9UDY8; MOD_RES 141; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q9UDY8 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 3V4L; |
| Mapped Pubmed ID | 11387339; 12466851; 12819136; 14576442; 14614861; 15741177; 16432253; 16495340; 16602821; 16831874; 16862125; 17095601; 17101977; 17202357; 17287209; 17462996; 17660823; 18192506; 18223652; 18941215; 19112107; 19139169; 19454668; 19915568; 19917778; 20562862; 20605784; 21041303; 21267068; 21448133; 21873235; 22366302; 22689981; 23114599; 23401595; 23706741; 24792914; 24825920; 24917592; 25202022; 25319413; 25456129; 25748427; 25762782; 25826454; 25965667; 25982276; 26386283; 26392569; 26405015; 26525107; 26668357; 26787500; 27032818; 27068814; 27105502; 27551157; 27681433; 27926862; 28031341; 28658621; 28928392; 29367251; 29414650; 29649481; 29901822; 29953499; 30025160; 30279415; 30375474; 30510167; 30564895; 30741923; 30979818; 30996332; 31092922; 31138793; 31313375; 31474984; 31632405; 31644910; 31659015; 32213560; 32343482; 33042160; 33092214; 33419765; 33827774; |
| Motif | MOTIF 377..384; /note=Nuclear export signal; /evidence=ECO:0000250|UniProtKB:Q9UDY8 |
| Gene Encoded By | |
| Mass | 93,216 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |