| IED ID | IndEnz0002002602 |
| Enzyme Type ID | protease002602 |
| Protein Name |
Apoptosis inhibitor 1 IAP-1 |
| Gene Name | IAP1 |
| Organism | Autographa californica nuclear polyhedrosis virus (AcMNPV) |
| Taxonomic Lineage | Viruses Naldaviricetes Lefavirales Baculoviridae Alphabaculovirus Autographa californica multiple nucleopolyhedrovirus Autographa californica nuclear polyhedrosis virus (AcMNPV) |
| Enzyme Sequence | MNEDTPPFYFISVCDNFRDNTAEHVFDMLIERHSSFENYPIENTAFINSLIVNGFKYNQVDDHVVCEYCEAEIKNWSEDECIEYAHVTLSPYCAYANKIAERESFGDNITINAVLVKEGKPKCVYRCMSNLQSRMDTFVNFWPAALRDMITNIAEAGLFYTGRGDETVCFFCDCCVRDWHTNEDTWQRHAAENPQCYFVLSVKGKEFCQNSITVTHVDKRDDDNLNENADDIEEKYECKVCLERQRDAVLMPCRHFCVCVQCYFGLDQKCPTCRQDVTDFIKIFVV |
| Enzyme Length | 286 |
| Uniprot Accession Number | P41435 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Acts by blocking cellular apoptosis early in infection. Later, stimulates caspase-3-like protease activity and induces apoptosis, probably to favor the release of occluded virions. {ECO:0000269|PubMed:19727595, ECO:0000269|PubMed:21795471}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Metal binding (4); Repeat (2); Zinc finger (1) |
| Keywords | Apoptosis;Host-virus interaction;Metal-binding;Modulation of host cell apoptosis by virus;Reference proteome;Repeat;Zinc;Zinc-finger |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 33,320 |
| Kinetics | |
| Metal Binding | METAL 169; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00029; METAL 172; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00029; METAL 189; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00029; METAL 196; /note=Zinc; /evidence=ECO:0000255|PROSITE-ProRule:PRU00029 |
| Rhea ID | |
| Cross Reference Brenda |