| IED ID | IndEnz0002002708 |
| Enzyme Type ID | protease002708 |
| Protein Name |
Pheromone-processing carboxypeptidase kex1 EC 3.4.16.6 Carboxypeptidase D |
| Gene Name | kex1 Pc16g01980 |
| Organism | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Penicillium Penicillium chrysogenum species complex Penicillium rubens Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
| Enzyme Sequence | MLLSALSLLLSPLVSASSAADYYVRSLPGAPEGPFLKMHAGHIEVDPDTNGNLFFWHFQNRHIANRQRTVIWLNGGPGCSSMDGAFMEVGPYRLQDDHTLKYNEGRWDEFANLLFVDNPVGTGFSYANTNSYLHELDEMAAHFVIFLEKFFELFPEYANDDLYIAGESYAGQHIPYIAKAIQDRNKGITENGGTKWPLKGLLIGNGWISPADQYPSYFKFIEREGLAKPGTSLHHNINALNEVCLSKLETPGAKNKLDVGACELVLQQFLDLTTEDHQCYNMYDVRLKDEAKSCGMNWPPDLKNIEPYLQRPDVVKALNINPAKKSGWTECAGMVHMAFTAKNSIPSVHLLPGLIESGINVLLFSGDKDLICNHIGTETLIHNMDWKGGTGFETSPGVWAPRHDWSFEGEPAGIYQSARNLTYVLFYNSSHMVPFDNPRQSRDMLDRFMKVDIASIGGQPSDSRIDGEKLPQTAVGGQANSTAAEQNEKERLKQTEMHAYTKSGEAVLIIVIIGVIAWGFFIWRSRRTRRGYKGVSNNDMSDSTSVLSRFQNKHSGRDVEAGDFDEAELDQLHSPSIEREDYAVGEASDDDDHIISHPETGGNRQSS |
| Enzyme Length | 607 |
| Uniprot Accession Number | B6H7A4 |
| Absorption | |
| Active Site | ACT_SITE 168; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 369; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074; ACT_SITE 431; /evidence=ECO:0000255|PROSITE-ProRule:PRU10074 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferential release of a C-terminal arginine or lysine residue.; EC=3.4.16.6; |
| DNA Binding | |
| EC Number | 3.4.16.6 |
| Enzyme Function | FUNCTION: Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (2); Glycosylation (3); Region (2); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Apoptosis;Carboxypeptidase;Glycoprotein;Golgi apparatus;Hydrolase;Membrane;Protease;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..19; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 67,721 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |