| IED ID | IndEnz0002002725 |
| Enzyme Type ID | protease002725 |
| Protein Name |
Kallikrein-10 EC 3.4.21.- Normal epithelial cell-specific 1 Protease serine-like 1 |
| Gene Name | KLK10 NES1 PRSSL1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MRAPHLHLSAASGARALAKLLPLLMAQLWAAEAALLPQNDTRLDPEAYGSPCARGSQPWQVSLFNGLSFHCAGVLVDQSWVLTAAHCGNKPLWARVGDDHLLLLQGEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITILSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN |
| Enzyme Length | 276 |
| Uniprot Accession Number | O43240 |
| Absorption | |
| Active Site | ACT_SITE 86; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 137; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 229; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Has a tumor-suppressor role for NES1 in breast and prostate cancer. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Beta strand (15); Chain (1); Disulfide bond (6); Domain (1); Glycosylation (1); Helix (5); Natural variant (2); Signal peptide (1); Turn (1) |
| Keywords | 3D-structure;Cell cycle;Disulfide bond;Glycoprotein;Hydrolase;Protease;Reference proteome;Secreted;Serine protease;Signal;Tumor suppressor |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..30; /evidence=ECO:0000255 |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 5LPE; 5LPF; |
| Mapped Pubmed ID | 11705853; 11920956; 12087468; 12970725; 14696124; 14972646; 16169070; 16254462; 16647913; 16800732; 16800735; 16800740; 16928223; 17182177; 17937626; 18515984; 18854834; 18855978; 19064572; 19085836; 19383315; 19558318; 19560453; 19760608; 20086175; 20680316; 20686372; 21487810; 21988832; 22102857; 22437349; 22874102; 23250777; 23268413; 23413953; 23499583; 24409072; 25153389; 25517869; 25553760; 25649006; 26172508; 26479703; 26616394; 27611765; 27825132; 28419837; 28559305; 29095848; 29231994; 29690914; 29807015; 31119602; 32386481; |
| Motif | |
| Gene Encoded By | |
| Mass | 30,170 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda | 3.4.21.B41; |