| IED ID | IndEnz0002002769 |
| Enzyme Type ID | protease002769 |
| Protein Name |
Aminopeptidase Y EC 3.4.11.15 |
| Gene Name | APE3 YBR286W YBR2024 |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MHFSLKQLAVAAFYATNLGSAYVIPQFFQEAFQQEEPIENYLPQLNDDDSSAVAANIPKPHIPYFMKPHVESEKLQDKIKVDDLNATAWDLYRLANYSTPDYGHPTRVIGSKGHNKTMEYILNVFDDMQDYYDVSLQEFEALSGKIISFNLSDAETGKSFANTTAFALSPPVDGFVGKLVEIPNLGCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGEPTKHTVATVGVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQNIIADTKHGDPDNIVALGAHSDSVEEGPGINDDGSGTISLLNVAKQLTHFKINNKVRFAWWAAEEEGLLGSNFYAYNLTKEENSKIRVFMDYDMMASPNYEYEIYDANNKENPKGSEELKNLYVDYYKAHHLNYTLVPFDGRSDYVGFINNGIPAGGIATGAEKNNVNNGKVLDRCYHQLCDDVSNLSWDAFITNTKLIAHSVATYADSFEGFPKRETQKHKEVDILNAQQPQFKYRADFLII |
| Enzyme Length | 537 |
| Uniprot Accession Number | P37302 |
| Absorption | |
| Active Site | ACT_SITE 358; /note=Proton acceptor; /evidence=ECO:0000250|UniProtKB:P80561 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Preferentially, release of N-terminal lysine.; EC=3.4.11.15; |
| DNA Binding | |
| EC Number | 3.4.11.15 |
| Enzyme Function | |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Glycosylation (8); Metal binding (6); Propeptide (1); Sequence conflict (1); Signal peptide (1); Site (1) |
| Keywords | Aminopeptidase;Direct protein sequencing;Glycoprotein;Hydrolase;Metal-binding;Metalloprotease;Protease;Reference proteome;Signal;Vacuole;Zinc;Zymogen |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Vacuole. Note=Lysosome-like vacuoles. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10551827; 11283351; 11805837; 14660704; 17651441; 19001347; 19536198; 22034500; 22261724; 23275495; 24040173; 27221740; 8674980; |
| Motif | |
| Gene Encoded By | |
| Mass | 60,137 |
| Kinetics | |
| Metal Binding | METAL 314; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 326; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 326; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 359; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 387; /note=Zinc 1; catalytic; /evidence=ECO:0000250|UniProtKB:P80561; METAL 472; /note=Zinc 2; catalytic; /evidence=ECO:0000250|UniProtKB:P80561 |
| Rhea ID | |
| Cross Reference Brenda |