| IED ID | IndEnz0002002792 |
| Enzyme Type ID | protease002792 |
| Protein Name |
Inter-alpha-trypsin inhibitor heavy chain H4 ITI heavy chain H4 ITI-HC4 Inter-alpha-inhibitor heavy chain 4 Inter-alpha-trypsin inhibitor family heavy chain-related protein IHRP Major acute phase protein MAP |
| Gene Name | ITIH4 IHRP |
| Organism | Sus scrofa (Pig) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Suina Suidae (pigs) Sus Sus scrofa (Pig) |
| Enzyme Sequence | MKTLSPTGYGLLLVLPLLLAVLQSTTAHKNDINIYSLTVDSKVSSRFAHTVVTSRVVNKGSAVQEATFQMELPKKAFITNFSMIIDGVTYPGNIKEKAAAQEQYSAVARGESAGLVRATGRKTEQFQVAVSVAPAAKVTFELVYEELLARHLGVYELLLKIQPQQLVKHLQMDIHIFEPQGISFLETESTFMTNELAEALTISQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNFIVRYDVNRTVTGGSIQIENGYFVHYFAPEVWSAIPKNVIFVIDTSGSMRGRKIQQTREALIKILGDLGSRDQFNLVSFSGEAPRRRAVAASAENVEEAKSYAAEIHAQGGTNINDAMLMAVQLLERANREELLPARSVTFIILLTDGDPTVGETNPSKIQKNVREAIDGQHSLFCLGFGFDVPYAFLEKMALENGGLARRIYEDSDSALQLEDFYQEVANPLLRLVAFEYPSNAVEEVTQDNFRLFFKGSELVVAGKLRDQSPDVLSAKVRGQLHMENVTFVMESRVAEQEAEFLSPKYIFHSFMERLWAYLTIQQLLAQTVSASDAEKKALEARALSLSLNYSFVTPLTSMVITKPEGQEQSQVAEKPVENGNRQGNTHSGHSSFQFHSVGDRTSRLTGGSSVDPVFSHRRGWKGQAQGFEKMSYLPPRLGPPGPLQPTRFSHPFSRITLDRVLPEVLSVPDETSHDMDSRIIGATIPPPPARIQAPSVILPLPGQSVDQLCVDLKHSQGPVKLLSDPGQGVEVTGHYEREKARFSWIEVTFKHPPLQVRASLEHIVVIRNRQSSAYKWKETLYSVMPGLKITMDKAGLLLLSSPNRVTIGLLSWDGPGKGLRLLLRDTDHFSSQISGTFGQFYQDVVWGPPAAADDSKRTVTVQGHDHSATRELKLDYQEGSPGKEISCWTVVL |
| Enzyme Length | 921 |
| Uniprot Accession Number | P79263 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration. {ECO:0000269|PubMed:10712621}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Disulfide bond (1); Domain (2); Frameshift (1); Glycosylation (6); Region (1); Sequence caution (1); Sequence conflict (2); Signal peptide (1) |
| Keywords | Acute phase;Direct protein sequencing;Disulfide bond;Glycoprotein;Protease inhibitor;Reference proteome;Secreted;Serine protease inhibitor;Signal |
| Interact With | |
| Induction | INDUCTION: Levels increase significantly after cardiogenic shock. Specifically induced by the cytokine IL6 in hepatocytes. {ECO:0000269|PubMed:10712621, ECO:0000269|PubMed:1697703}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10712621}. |
| Modified Residue | |
| Post Translational Modification | PTM: Appears to be both N- and O-glycosylated. {ECO:0000250}.; PTM: Cleaved by plasma kallikrein to yield 55- and 25-kDa fragments. |
| Signal Peptide | SIGNAL 1..27; /evidence="ECO:0000269|PubMed:7556597, ECO:0000269|PubMed:8830057" |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 102,146 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |