| IED ID | IndEnz0002002798 |
| Enzyme Type ID | protease002798 |
| Protein Name |
Integrin alpha-1 Laminin and collagen receptor VLA-1 Fragment |
| Gene Name | ITGA1 |
| Organism | Gallus gallus (Chicken) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken) |
| Enzyme Sequence | ENMTFGTTLVTNPKGGFLACGPLYAYKCGRLHYTTGVCSNVSSTFETVKAVAPSVQECKTQLDIVIVLDGSNSIYPWESVTAFLNSLLRNMDIGPQQTQVGIVQYGQTVVHEFYLNTYSTTEEVMDAALRIRQRGGTQTMTALGIDTAREEAFTEAHGARRGVQKVMVIVTDGESHDNYRLQEVIDKCEDENIQRFAIAILGSYSRGNLSTEKFVEEIKSIASKPTEKHFFNVSDELALVTIVEALGERIFALEATTDQQAASFEMEMSQAGFSAHYSQDWVMLG |
| Enzyme Length | 285 |
| Uniprot Accession Number | Q90615 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Glycosylation (4); Non-terminal residue (2); Topological domain (1) |
| Keywords | Cell adhesion;Glycoprotein;Integrin;Membrane;Receptor;Reference proteome;Transmembrane |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 31,503 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |